Publications by authors named "C Buoso"
Graves' disease (GD) and gestational transient thyrotoxicosis (GTT) are the most common causes of thyrotoxicosis during pregnancy, with prevalence ranging from 0.1% to 1% and from 1% to 3%, respectively. Hyperthyroidism during pregnancy can have severe consequences if not promptly recognized and treated.
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- Treating hypothyroidism is complicated for patients with malabsorption, often requiring higher doses of oral levothyroxine (L-T4) due to impaired absorption.
- A case is presented of a young man with myxedema after undergoing biliopancreatic diversion surgery, showing severe hypothyroidism symptoms and requiring intravenous treatments.
- The case highlights the importance of monitoring Thyroid Stimulating Hormone (TSH) levels more frequently in post-bariatric surgery patients and suggests that liquid forms of L-T4 may be more effective than tablets in these cases.
Background: Advanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact on Glycemia Risk Index (GRI) and other continuous glucose monitoring (CGM) metrics when switching from one of four insulin strategies to AHCL in type 1 adult patients.
Methods: A single-center, retrospective pre/post observational study; 198 patients (age 44.
Background: The potential impact of diabetes mellitus type 1 (DM1) on male fertility is currently poorly defined. Hyperglycaemia and insulin deficiency may affect spermatogenesis. Some evidence suggests that men with DM1 have a significant reduction in progressive sperm motility, sperm morphology and semen volume, without significant changes in sperm concentration and count, but definite data are lacking.
View Article and Find Full Text PDFImbalances of iron and dopamine metabolism along with mitochondrial dysfunction have been linked to the pathogenesis of Parkinson's disease (PD). We have previously suggested a direct link between iron homeostasis and dopamine metabolism, as dopamine can increase cellular uptake of iron into macrophages thereby promoting oxidative stress responses. In this study, we investigated the interplay between iron, dopamine, and mitochondrial activity in neuroblastoma SH-SY5Y cells and human induced pluripotent stem cell (hiPSC)-derived dopaminergic neurons differentiated from a healthy control and a PD patient with a mutation in the α-synuclein (SNCA) gene.
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