Effects of symptom reduction and psychotropic medication on cognitive impairment in depression.

Background: Depression is related to cognitive performance. This follow-up study examines the influence of depression symptoms and psychopharmacological treatment on change in the cognitive performance of patients with depressive episodes over a 2-year period.

Sampling And Methods: Sixty-two in- and outpatients with depression of varying severity (ICD-10: F31-F33) were examined in an open prospective naturalistic observational study with 3 points of measurement and tested by use of 3 computerized cognitive performance tests [Visual Attentiveness Test (VAT), Continuous Attention Test (CAT), Word Recognition Test (WRT)], while the psychotropic medication was classified by subclass and dosage.

[Do cognitive deficits in depressive disorders remit?].

Objective: The importance of cognitive deficits concerning schizophrenics is well-known. Much less material of that kind has been collected from patients with affective disorders, which was the aim of this clinical study.

Methods: Inclusion criterions were in- and outpatients with affective disorders (ICD-10: F31-F33) aged < 61.

Transcription of proto-oncogenes in Rous sarcoma virus infected and transformed chicken embryo cells.

To evaluate an effect of infection by RSV on the transcriptional activity of proto-oncogenes, we tested 19 cellular oncogenes and the beta-actin gene performing "nuclear run on transcription assays" using nuclei isolated from RSV infected or transformed chick embryo cells (CEC). A drastic increase in the transcriptional activity of the c-fgr proto-oncogene and a slight increase of c-fos and c-myc could be observed in uninfected compared to RSV infected CEC. To distinguish between infection- and transformation-dependent alterations we used the transformation-defective temperature-sensitive RSV mutant strain NY 68.