Publications by authors named "C Bucci"
Background: Extracellular vesicles (EVs) are a group of nanoscale cell-derived membranous structures secreted by all cell types, containing molecular cargoes involved in intercellular communication. EVs can be used to mimic "nature's delivery system" to transport nucleic acids, peptides, lipids, and metabolites to target recipient cells. EVs offer a range of advantages over traditional synthetic carriers, thus paving the way for innovative drug delivery approaches that can be used in different diseases, including cancer.
View Article and Find Full Text PDFOptimal Operation of Cryogenic Calorimeters Through Deep Reinforcement Learning.
Comput Softw Big Sci
May 2024
Cryogenic phonon detectors with transition-edge sensors achieve the best sensitivity to sub-GeV/c dark matter interactions with nuclei in current direct detection experiments. In such devices, the temperature of the thermometer and the bias current in its readout circuit need careful optimization to achieve optimal detector performance. This task is not trivial and is typically done manually by an expert.
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- * Different bacteria, including Gram-negative types and their outer membrane vesicles (OMVs), can trigger pyroptosis in various cell types, which affects inflammation and barriers in our body, but more research is needed to fully understand these effects.
- * The review will delve into how pyroptosis pathways differ between harmful and harmless bacteria, while also examining experimental models and potential treatments that target these pathways to improve infection management.
Mitophagy is the intracellular recycling system that disposes damaged/inefficient mitochondria and allows biogenesis of new organelles to ensure mitochondrial quality is optimized. Dysfunctional mitophagy has been implicated in human aging and diseases. Multiple evolutionarily selected, redundant mechanisms of mitophagy have been identified, but their specific roles in human health and their potential exploitation as therapeutic targets are unclear.
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- * A study using a reference strain and a knockout mutant showed that the HrpA/HrpB system is essential for disease progression, as the mutant exhibited impaired spreading and replication in the brain of infected mice.
- * Analysis of infected brain samples revealed that the mutant had reduced activation of key pyroptosis pathways and inflammatory markers, indicating that HrpA/HrpB is crucial for inducing pyroptosis during meningococcal infection.