Publications by authors named "C Brunaud"
IKKα, encoded by CHUK, is crucial in the non-canonical NF-κB pathway and part of the IKK complex activating the canonical pathway alongside IKKβ. The absence of IKKα causes fetal encasement syndrome in humans, fatal in utero, while an impaired IKKα-NIK interaction was reported in a single patient and causes combined immunodeficiency. Here, we describe compound heterozygous variants in the kinase domain of IKKα in a female patient with hypogammaglobulinemia, recurrent lung infections, and Hay-Wells syndrome-like features.
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- Radiotherapy for brain tumors can cause cognitive impairments, and this study explores how deformation-based morphometry (DBM) using Jacobian determinants can help detect vulnerable areas in the brain after radiation exposure in an animal model.
- Rats underwent whole-brain irradiation (WBI, 30 Gy), and a series of MRI tests over six months assessed both macroscopic and microscopic brain changes, focusing on cerebral blood volume and diffusion metrics.
- The results indicated specific brain regions, such as the corpus callosum and cortex, displayed both transient and lasting structural changes due to radiation, highlighting DBM's potential for identifying at-risk brain areas in future patient treatments.
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- * In a study using PET imaging on glioblastoma models, the injected [Cu]-FAU nanocrystals accumulated rapidly in tumor areas while avoiding healthy brain tissue, with uptake kinetics varying between different glioblastoma models (U87-MG and U251-MG).
- * The research confirmed the presence of zeolite nanocrystals in the tumors and demonstrated the potential of this radiolabeling technique for precise PET tracking, supporting the use of zeolite nanocr
Article Synopsis
- * A female patient with genetic variants in the IKKα kinase domain exhibited severe immune issues, including low antibody levels and recurrent lung infections, linked to the impaired NF-κB pathways.
- * The study highlights that mutations in IKKα disrupt its function, paving the way for better understanding of NF-κB pathway defects and IKKα's influence on gene expression in humans.
Article Synopsis
- The study focused on understanding the tumor microenvironment (TME) of brain metastases (BM) from lung cancer, specifically looking at factors like hypoxia and redox state, which impact tumor growth and treatment resistance.
- In vitro experiments showed that lung cancer cells increased certain proteins in response to low oxygen levels (hypoxia), indicating metabolic and oxidative stress changes in the tumor tissue.
- Imaging techniques, particularly [Cu][Cu(ATSM)] PET, revealed significant differences in hypoxia levels and protein expressions between cortical and striatal brain metastases, highlighting the importance of this imaging method in tailoring treatment approaches based on tumor characteristics.