[Open study of clotiazepam (Clozan) in ambulatory anxious patients centered on a multifactorial evaluation using the AMDP and on a study of the rebound effect].

The efficacy and tolerance of the first thienodiazepine, clotiazepam, is well established but its clinical spectrum and the possibility of a rebound effect upon its cessation needed further research. Moreover, the validity of the AMDP Anxiety scale had been tested but not yet its sensitivity to change. Clotiazepam was given in an "open" design to 42 anxious outpatients at the dosage of 3 X 5 to 3 X 10 mg daily during 1 month, followed by a 1-week "single blind" placebo period.

[Acute porphyria and psychiatry. Updating our knowledge].

On the occasion of a clinical case of acute porphyria, the authors review the present knowledge on the biochemistry, pathophysiology, clinical picture, diagnosis and therapy of this group of disorders. They stress their importance in psychiatry and present two lists of authorized vs contra-indicated drugs in these disorders.

[Computerized letter to the attending physician. Practical application of the AMDP (Association of Methodology and Documentation in Psychiatry)].

The authors have elaborated a micro-computerized program which enables --on the basis of the Psychopathology Form (plus optionally the Somatic Form) of the AMDP-System and of an open-language diagnosis and treatment --to print out instantly a semi-standardized letter and a syndromic profile of 10 or 13 factors. This realization is favorably acknowledged by general practitioners and medical inspectors thanks to its speed of transmission, to its brevity and to the clarity of the syndromic reduction of the clinical picture. Other advantages lie in the greater validity of factor scores as compared to items scores, the standardization and readability of the clinical files, and the extension of the AMDP data bank.

[Factor analysis of the French revision of the AMDP rating scales. Results of an international study of 388 cases].

A total of 388 patients from 10 Belgian and French Centers were evaluated with the 1981 revision of the psychopathological and somatic scales of the AMDP System. Principal components factor analyses indicate that the somatic items contribute little to the structure. A 10-factors solution of the psychopathological items generate the following factors after orthogonal rotation: Obsessions-Phobias, Dramatization, Anxiety, Depression, Retardation, Organicity, Dissociation, Delusions, Mania, Dysphoria.