Publications by authors named "C Broda"

Article Synopsis
  • * A study was conducted on 9 adult patients with congenital heart disease who received durable mechanical support for at least 3 years, showing varied heart anatomies and successful outcomes.
  • * The use of the HeartMate 3 device resulted in few complications, making it a viable option for patients either waiting for a transplant or needing long-term support.
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Background: Given increased survival for adults with CHD, we aim to determine outcome differences of infective endocarditis compared to patients with structurally normal hearts in the general population.

Methods: We conducted a retrospective cross-sectional study identifying infective endocarditis hospitalisations in patients 18 years and older from the National Inpatient Sample database between 2001 and 2016 using International Classification of Disease diagnosis and procedure codes. Weighting was used to create national annual estimates indexed to the United States population, and multivariable logistic regression analysis determined variable associations.

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Article Synopsis
  • COVID-19 significantly affects coagulation in adult patients with congenital heart disease (ACHD), making them more susceptible to thromboembolic (TE) and bleeding complications.
  • In a study from May 2020 to November 2021 involving nearly 2,000 ACHD patients, 1.5% experienced severe TE or bleeding events, which were linked to higher mortality rates and more advanced health conditions.
  • Key risk factors for these complications included prior anticoagulation treatment, incidents of cardiac injury, and severity of the COVID-19 infection, with logistic regression confirming their independent associations with TE and bleeding risks.
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We present a case of anatomic repair of dextro-transposition of the great arteries (d-TGA) with ventricular septal defect (VSD) in a 55-year-old man who presented with acute heart failure. This case highlights the importance of multimodal imaging and multidisciplinary involvement in developing a comprehensive surgical and medical plan for adults with congenital heart disease. We think this is the oldest reported patient undergoing anatomic surgical repair of d-TGA with VSD.

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Patients with single-ventricle heart disease and failing Fontan circulation represent the largest and most rapidly growing subgroup of adults with congenital heart disease referred for transplant assessment. Few clinical therapies are available for improving Fontan hemodynamics. Mechanical circulatory support devices have been used successfully in the clinical setting to assist the single ventricle, but no device is currently available to support the subpulmonary circulation.

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