Publications by authors named "C Brigand"
Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) at interval cytoreductive surgery for ovarian cancer improves overall survival but its role in recurrent disease is uncertain. We aimed to compare outcomes in patients treated with or without HIPEC during surgery for recurrent ovarian cancer.
Methods: The multicentre, open-label, randomised, phase 3 CHIPOR trial was conducted at 31 sites in France, Belgium, Spain, and Canada, and enrolled patients with first relapse of epithelial ovarian cancer at least 6 months after completing platinum-based chemotherapy.
Article Synopsis
- This study analyzed 151 cases of mediastinitis at Strasbourg University Hospital, focusing on patient demographics, infection sources, and treatment outcomes over a decade.
- Cases included poststernotomy mediastinitis (PSM), mediastinitis from esophageal perforation (MEP), and descending necrotizing mediastinitis (DNM), with distinct microbial profiles noted: PSM was mostly caused by staphylococci, while MEP and DNM showed a mix of organisms from digestive or oral sources.
- The findings indicated a median anti-infective treatment duration of 41 days and a 1-year survival rate of 64.8%, highlighting the importance of understanding infection origins for better management strategies.
Introduction: Parastomal hernia repair is a real surgical challenge because of the high rate of recurrence. The Stapled Mesh Stoma Reinforcement Technique (SMART) is a keyhole-like technique in which the mesh is stapled to the fascia using a circular mechanical stapler.
Methods: A prospective study from January 2021 to February 2023 was conducted including all patients operated with the SMART technique.
Background: Although several prognostic factors in GIST have been well studied such as tumour size, mitotic rate, or localization, the influence of microscopic margins or R1 resection remains controversial. The aim of this study was to evaluate the influence of R1 resection on the prognosis of GIST in a large multicentre retrospective series of patients.
Methods: From 2001 to 2013, 1413 patients who underwent surgery for any site of GIST were identified from 61 European centers.
We analyzed whether preoperative F-FDG PET/CT adds to conventional primary staging in patients with presumed non-metastatic colonic cancer (CC). The prognostic role of F-FDG uptake in the primary tumor was evaluated after a mean follow-up of 15 years. Patients with a new diagnosis of presumed localized CC were prospectively enrolled and underwent presurgical F-FDG PET/CT.
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