Publications by authors named "C Brett"
BRAFV600E/pTERT double mutated papillary thyroid cancers exhibit immune gene suppression.
Front Endocrinol (Lausanne)
December 2024
Introduction: BRAFV600E mutation (BRAF) is common in papillary thyroid cancer (PTC), and most patients have an excellent outcome. However, a TERT-promoter mutation (pTERT) in the presence of BRAF (BRAFpTERT) has been demonstrated to confer a more aggressive behavior to PTC. Lymphocytic infiltration is often present in PTC.
View Article and Find Full Text PDFImproving the Timely Delivery of Postoperative Radiation in Head and Neck Cancer.
Pract Radiat Oncol
January 2025
Article Synopsis
- - The timing between a patient's tumor removal surgery and subsequent radiation treatment is crucial for improving their chances of recovery and survival, highlighting the need for effective management in healthcare settings.
- - Current compliance rates for timely treatment are under 50%, indicating a significant gap between established goals and actual practice.
- - The article offers practical tools for clinicians to use lean healthcare principles and flow management to identify and tackle obstacles that delay patient care.
Article Synopsis
- Scientists made special antibodies that can find a molecule called CoA in different tests.
- They used these antibodies with another technique to discover many proteins in bacteria and mammals that are changed by CoA, especially when the cells are stressed.
- They found that when cells are exposed to something like hydrogen peroxide, these changes mostly happen in proteins found in the mitochondria, which are the cell's energy factories.
Sphingolipids are essential in membrane trafficking and cellular homeostasis. Here, we show that sphingolipids containing very long-chain fatty acids (VLCFAs) promote homotypic vacuolar fusion in Saccharomyces cerevisiae. The elongase Elo3 adds the last two carbons to VLCFAs that are incorporated into sphingolipids.
View Article and Find Full Text PDFArticle Synopsis
- Foramen magnum stenosis (FMS) is a serious condition in infants with achondroplasia that can lead to sudden infant death, and the Achondroplasia Foramen Magnum Score (AFMS) is used to classify its severity for potential neurosurgery.
- This study reviewed follow-up MRI scans of infants with AFMS3 to assess how their condition evolves, finding that 41% experienced worsening, while 36% improved.
- The authors recommend regular MRI follow-ups every 6 months for infants with AFMS3, given the significant risk of progression that may require surgical intervention.