Balancing Protection and Quality in Big Data Analytics Pipelines.

Existing data engine implementations do not properly manage the conflict between the need of protecting and sharing data, which is hampering the spread of big data applications and limiting their impact. These two requirements have often been studied and defined independently, leading to a conceptual and technological misalignment. This article presents the architecture and technical implementation of a data engine addressing this conflict by integrating a new governance solution based on access control within a big data analytics pipeline.

A proposal for a new scoring system to evaluate pelvic masses: Pelvic Masses Score (PMS).

Objectives: Ovarian cancer is the fourth leading cause of death among neoplastic diseases in women. In spite of constant improvement in surgical, chemotherapeutic and immunologic techniques, which can induce long remission periods, the five-year survival rate has not really changed over the past thirty years. We tried to create a sonographic scoring system, called PMS, that could be helpful in diagnosis of pelvic masses.

Short-term outcomes with the Ajust™ system: a new single incision sling for the treatment of stress urinary incontinence.

Introduction And Hypothesis: To evaluate the efficacy and safety of the minimally invasive Ajust™ system in the treatment of stress urinary incontinence.

Methods: This was a prospective multicentre study. All patients with primary urodynamic stress urinary incontinence were prospectively selected to receive the Ajust™ procedure.

Hepatobiliary phospholipid transporter ABCB4, MDR3 gene variants in a large cohort of Italian women with intrahepatic cholestasis of pregnancy.

Background: Intrahepatic cholestasis of pregnancy is a multifactorial disorder of pregnancy associated with a genetic background.

Aim: To evaluate the genetic contribution of ABCB4, MDR3 gene in the development of intrahepatic cholestasis of pregnancy in a large cohort of Italian subjects.

Methods: This study represents an extension of a previous multicentre-prospective study including three Italian referral centres.

Intrahepatic cholestasis of pregnancy: three novel MDR3 gene mutations.

Background: The aetiology of intrahepatic cholestasis of pregnancy is unknown, but more than 10 different MDR3 gene mutations have recently been identified.

Aim: To evaluate the genetic contribution of the MDR3 gene in the pathogenesis of intrahepatic cholestasis of pregnancy in Italian subjects.

Methods: We performed a multicentre prospective case-control study, enrolling 80 women with intrahepatic cholestasis of pregnancy at the third trimester of pregnancy and 80 pregnant women without intrahepatic cholestasis of pregnancy.