Publications by authors named "C Bourguignon"
Background: Chronic Limb-Threatening Ischemia (CLTI) represents the most advanced stage of Peripheral Artery Disease (PAD) and is associated with dire prognosis, characterized by a substantial risk of limb amputation and diminished life expectancy. Despite significant advancements in therapeutic interventions, the underlying mechanisms precipitating the progression of PAD to CLTI remain elusive.
Methods: Considering diabetes is one of the main risk factors contributing to PAD exacerbation into CLTI, we compared hind limb ischemia recovery in HFD STZ vs.
Infradian mood and sleep-wake rhythms with periods of 48 hours and beyond have been observed in patients with bipolar disorder (BD), which even persist in the absence of exogenous timing cues, indicating an endogenous origin. Here, we show that mice exposed to methamphetamine in drinking water develop infradian locomotor rhythms with periods of 48 hours and beyond which extend to sleep length and manic state-associated behaviors in support of a model for cycling in BD. The cycling capacity is abrogated upon genetic disruption of dopamine (DA) production in DA neurons of the ventral tegmental area (VTA) or ablation of nucleus accumbens projecting DA neurons.
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- The study explored how increased oxygen extraction fraction (OEF) affects the recovery of diffusion-weighted imaging (DWI) lesions in stroke patients who underwent thrombectomy after acute ischemic events.
- It analyzed data from the HIBISCUS-STROKE cohort, focusing on DWI and perfusion magnetic resonance imaging results to understand the relationship between OEF levels and changes in ischemic lesion volume.
- Results showed that patients with increased OEF within their DWI lesions experienced a significant reduction in lesion volume compared to those without increased OEF, suggesting that higher OEF may be a positive indicator for recovery post-thrombectomy.