Insight into some of the signaling pathways triggered by a lipid immunomodulator.

The use of non specific immunomodulatory agents takes an important place in the aspecific host response to invading microorganisms. In this context, antimicrobial properties of royal jelly have been ascribed to organic acids (mainly 10 hydroxy-2-decenoic acid or 10-HDA) and proteins. We synthesized a derivative of 10-HDA, the 1-(2-methoxyethoxymethyl)2,3-(10-hydroxy2-decenoyl)(E) glycerol referred as diHDA-glycerol which was previously found to protect mice against virulent Salmonella typhimurium challenge through more adequate immune regulations.

[The Rel/NF-kappa-B transcription factors: complex role in cell regulation].

The transcription factor NF-kappa B has attracted widespread attention among researchers. NF-kappa B displays some original characteristics including rapid regulation, the wide range of genes that it controls and its probable involvement in several diseases. In resting cells, NF-kappa B is kept in an inactive form in the cytoplasm where it is bound to a member of the I kappa B family of inhibitory proteins.

Effect of a synthetic lipid immunomodulator on the regulation of the transcription factor NF-kappaB.

Macrophage activation plays a central role in host defense against a variety of pathogens via inducible messengers. The transcription factor NF-kappaB controls the synthesis of cytokines involved in immune responses. In quiescent cells, NF-kappaB is located in the cytosol bound to an inhibitor IkappaB.

6-Allyl-5,6-dihydro-5-hydroxypyran-2-one, a lactone produced by a new Drechslera species: specified 1H and 13C NMR assignments, mutagenic and immunomodulating testings.

A lactone (6-allyl-5,6-dihydro-5-hydroxypyran-2-one) was isolated from a new Drechslera sp. 1H and 13C NMR assignments, not previously specified, are published. No mutagenic activity on Ames/Salmonella test (strains TA98 and TA100 has been observed.

In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall. (Asteraceae).

The immunomodulating properties of arglabin, a sesquiterpene lactone isolated from Artemisia myriantha Wall. (Asteraceae) were investigated using the murine macrophage tumor line J774.1.