Publications by authors named "C Bossi"
Article Synopsis
- Radiotherapy combined with pembrolizumab showed potential benefits for patients with recurrent glioblastoma, particularly in those previously treated with bevacizumab.
- In a study with 60 patients, the majority tolerated the treatment well, with overall survival rates of 57% in the bevacizumab-continuing group.
- Increased levels of activated T cells in tumors were observed, indicating a positive immune response; further trials are recommended to explore this treatment's efficacy, especially for those who haven't received bevacizumab.
Unlabelled: We investigated the effectiveness of navtemadlin (KRT-232) in treating recurrent glioblastoma. A surgical window-of-opportunity trial ( NCT03107780 ) was conducted on 21 patients to determine achievable drug concentrations within tumor tissue and examine mechanisms of response and resistance. Both 120 mg and 240 mg daily dosing achieved a pharmacodynamic impact.
View Article and Find Full Text PDFPersonality traits have been associated with sleep problems and stress experience. However, their impact on objective sleep and the temporal relationship of stress on sleep has remained elusive. This study examined whether daytime stress predicts sleep the following night, and the moderating role of neuroticism and conscientiousness in this relationship.
View Article and Find Full Text PDFAims: Restrictions imposed to prevent SARS-CoV-2 transmission should be weighed against consequences on vulnerable groups' health. Lifestyles and disease management of older people with diabetes might have been differentially impacted compared to non-chronic individuals.
Methods: A cross-sectional study (LOST in Lombardia) was conducted on a representative full sample of 4 400 older adults (17-30 November 2020), collecting data on lifestyles, mental health and access to care before and during the pandemic.