Publications by authors named "C Borras"
Centenarians and their relatives possess a notable survival advantage, with higher longevity and reduced susceptibility to major age-related diseases. To date, characteristic omics profiles of centenarians have been described, demonstrating that these individuals with exceptional longevity regulate their metabolism to adapt and incorporate more resilient biomolecules into their cells. Among these adaptations, the lipidomic profile stands out.
View Article and Find Full Text PDFBackground And Aims: Low-density lipoprotein (LDL) aggregation is nowadays considered a therapeutic target in atherosclerosis. DP3, the retro-enantio version of the sequence Gly-Cys of LRP1, efficiently inhibits LDL aggregation and foam cell in vitro formation. Here, we investigate whether DP3 modulates atherosclerosis in a humanized ApoB100, LDL receptor (LDLR) knockout mice (LdlrhApoB100 Tg) and determine the potential LDL-related underlying mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- * After treatment with PCSK9 inhibitors, plasma from FH patients showed altered cholesterol distribution, with less cholesterol in LDL and more in HDL.
- * PCSK9 inhibitors enhanced the movement of cholesterol to feces in specific mouse models and support the reverse cholesterol transport pathway in patients with heterozygous FH.
Article Synopsis
- - Alzheimer's disease is complex and requires diverse treatment strategies focused on preventing dementia progression and managing the disease over the long term.
- - Lifestyle changes and dietary supplements are being explored as viable, low-toxicity options to support cognitive health.
- - A clinical trial shows that genistein, a phytoestrogen in soy, can significantly preserve cognitive function in individuals at early stages of Alzheimer's, highlighting the importance of dietary compounds in Alzheimer's management.