This study introduces a novel method for producing Ag nanoclusters (NCs) within GeO-PbO glasses doped with Tm ions. Sample preparation involved the melt-quenching method, employing adequate heat treatment to facilitate Ag NC formation. Absorption spectroscopy confirmed trivalent rare-earth ion incorporation.
View Article and Find Full Text PDFRandom lasers have been studied using many materials, but only a couple have used glass matrices. Here, we present a study of zinc tellurite and aluminum oxide doped with different percentages of neodymium oxide (4 wt.%, 8 wt.
View Article and Find Full Text PDFNd-doped GeO-PbO glass with silver (Ag) nanoparticles (NPs) are produced with double line waveguides through fs laser processing for photonic applications. A Ti:sapphire fs laser at 800 nm was used to write the waveguides directly into the glass 0.7 mm beneath the surface.
View Article and Find Full Text PDFThe discovery of two quinazolinones with selective, single-digit micromolar activity (IC = 6-7 µM) against the tachyzoites of the apicomplexan parasite Toxoplasma gondii is reported. These potent and selective third generation derivatives contain a benzyloxybenzyl substituent at C2 and a bulky aliphatic moiety at N3. Here we show that these quinazolinones inhibit T.
View Article and Find Full Text PDFWe designed and synthesised novel N-substituted 1,3-thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii efficacy. This scaffold was functionalised both at the N1-hydrazine portion with three structurally different moieties and at the lactam nitrogen with substituted benzyl groups selected on the basis of our previous structure-activity relationships studies. Using three different assay methods, the compounds were assessed in vitro to determine both the levels of efficacy against the tachyzoites of T.
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