Publications by authors named "C Bookwalter"
IV contrast media improve the diagnostic power of radiology examinations. These media include gadolinium-based contrast media and iron-oxide nanoparticles for MRI, iodinated contrast material for CT, microbubbles for ultrasound, and radiopharmaceuticals for nuclear medicine. As for all medications, contrast media carry risks, which may be heightened in the conditions of pregnancy and lactation.
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- Kinesin-1 motors transport vesicles through a complex microtubule network, with research focusing on how these cargoes navigate intersections.
- Multiple kinesin motors engage a lipid-based cargo, but only a few (typically up to three) are actively working on it at any time.
- The study developed a mathematical model that explains the observed behaviors at 2D and 3D intersections, revealing a consistent mechanism for cargo navigation that is similar across different motor proteins like myosin Va.
Article Synopsis
- The study aimed to create an automated system to extract important prostate cancer information from clinical notes, focusing on patients who had prostate MRIs.
- Researchers analyzed data from over 23,000 patients between 2017 and 2022, using advanced machine learning techniques (like BERT models) to classify data from sentences in the notes.
- The results indicated that the automated pipeline was highly effective at identifying cancer risk factors, outperforming radiologists in sensitivity, though it was slightly less accurate in classifying other clinical information.*
Multimodality Imaging of a Mass Arising from a Cor Triatriatum Sinister Membrane.
Radiol Cardiothorac Imaging
February 2024
Cor triatriatum sinister is a rare entity characterized by a membrane within the left atrium and posterior to the atrial appendage. This defect may cause obstructive symptoms analogous to mitral stenosis. The authors present a case of an incidentally detected enhancing mass originating from a cor triatriatum sinister membrane, with imaging characteristics most suggestive of myxoma.
View Article and Find Full Text PDFKinesin-1 ensembles maneuver vesicular cargoes through intersections in the 3-dimensional (3D) intracellular microtubule (MT) network. To characterize directional outcomes (straight, turn, terminate) at MT intersections, we challenge 350 nm fluid-like liposomes transported by ~10 constitutively active, truncated kinesin-1 KIF5B (K543) with perpendicular 2-dimensional (2D) and 3D intersections . Liposomes frequently pause at 2D and 3D intersections (~2s), suggesting that motor teams can simultaneously engage each MT and undergo a tug-of-war.
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