Global organelle profiling reveals subcellular localization and remodeling at proteome scale.

Defining the subcellular distribution of all human proteins and their remodeling across cellular states remains a central goal in cell biology. Here, we present a high-resolution strategy to map subcellular organization using organelle immunocapture coupled to mass spectrometry. We apply this workflow to a cell-wide collection of membranous and membraneless compartments.

Doxycycline post-exposure prophylaxis for preventing bacterial sexually transmitted infections (STIs): Are clinical providers supportive?

Background: Bacterial sexually transmitted infections (STIs) continue to increase in the United States. Despite evidence of the effectiveness of doxycycline post-exposure prophylaxis (Doxy-PEP) to prevent STIs, little is known about providers' attitudes and willingness to implement Doxy-PEP.

Methods: An online questionnaire was sent to 575 clinical providers in New York State in September 2022.

The Sdp-SH3b2 domain contained in N6.2-derived extracellular vesicles inhibit murine norovirus replication.

The internalization of N6.2 extracellular vesicles (EVs) by cells results in a significant induction of the 2',5'-oligoadenylate synthetase (OAS) pathway. It also induces expression of and .

Eco-geomorphic modelling response of tidal marshes to sea level rise and changes in suspended sediment supply.

Tidal marshes are coastal systems that provide valuable ecosystem services, highlighting coastal protection and carbon burial. For centuries, these dynamic ecosystems have kept pace with sea level rise through organic and mineral matter accumulation. In the current situation of accelerated sea-level rise and changes in suspended sediment concentrations, the evolution of these systems has gained special attention across scientific fields.

Scholars in Health Equity: A Program of Structured Physician Faculty Development.

Background: Structured faculty development programs focused on integrating health equity into medical education curricula remain limited.

Aim: To describe an interdisciplinary faculty development program grounded in adult learning theory and to assess its impact on participants' professional growth.

Setting And Participants: Twenty-one faculty members across six academic-affiliated health systems.