Publications by authors named "C Bonithon-Kopp"
Background: Smoking influence on poststroke prognosis remains controversial. These conflicting results could be due to some residual confounding factors not fully considered in previous studies, including social deprivation. This study aimed to assess the joint impact of deprivation and smoking on functional outcomes after ischemic stroke.
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- Social deprivation negatively impacts the 1-year survival rates of patients with ischemic stroke, with higher mortality observed in deprived individuals compared to those who are not deprived.
- The study involved 1,540 patients, using the EPICES score to evaluate individual social deprivation and found no significant difference in mortality within the first 90 days but a marked excess in mortality from 90 days to 12 months for deprived patients.
- In patients with intracerebral hemorrhage, social deprivation did not influence 12-month mortality, indicating that specific post-stroke care may be necessary for those with ischemic strokes who are socially deprived.
Social deprivation among socio-economic contrasted french areas: Using item response theory analysis to assess differential item functioning of the EPICES questionnaire in stroke patients.
PLoS One
July 2020
Article Synopsis
- A study evaluated the EPICES questionnaire, which measures social deprivation (precariousness), in different regions of France, including mainland France, French West Indies, and French Guiana.
- Using data from the INDIA study, which examined how social inequalities affect stroke patients, researchers analyzed 1,553 participants with a focus on Differential Item Functioning (DIF) across regions.
- Five specific items showed significant DIF, indicating varying interpretations based on local contexts, but overall, the EPICES score remained a reliable indicator of social deprivation despite these differences.
Aims: Mutations in PRKAG2, the gene encoding for the γ2 subunit of 5'-AMP-activated protein kinase (AMPK), are responsible for an autosomal dominant glycogenosis with a cardiac presentation, associating hypertrophic cardiomyopathy (HCM), ventricular pre-excitation (VPE), and progressive heart block. The aim of this study was to perform a retrospective time-to-event study of the clinical manifestations associated with PRKAG2 mutations.
Methods And Results: A cohort of 34 patients from 9 families was recruited between 2001 and 2010.
Background And Purpose: Although there is growing and convincing evidence that socially deprived patients are at higher risk of stroke and worse outcomes, it remains controversial whether or not they suffer more severe stroke. This study aimed to evaluate the influence of social deprivation on initial clinical severity in patients with stroke.
Methods: A total of 1536 consecutive patients with an acute first-ever stroke (both ischaemic stroke and intracerebral hemorrhage) were prospectively enrolled from six French study centers.