Publications by authors named "C Bond"
Aim: To highlight the use of corpus linguistics for analysing language data and to provide a worked example of this approach in nursing research.
Design: Methodology discussion paper.
Methods: This paper introduces corpus linguistics as a distinct approach to undertaking qualitative research in nursing.
Anticholinergic burden (ACB) from medications has been associated with adverse outcomes in older adults. The aim was to conduct a non-randomized feasibility study of an intervention to reduce the anticholinergic burden in older patients (REGENERATE) to inform a subsequent definitive trial. The development and evaluation of an ACB reduction intervention was guided by the Medical Research Council framework.
View Article and Find Full Text PDFThe proteins SFPQ (splicing Factor Proline/Glutamine rich) and NONO (non-POU domain-containing octamer-binding protein) are mammalian members of the Drosophila Behaviour/Human Splicing (DBHS) protein family, which share 76% sequence identity in their conserved 320 amino acid DBHS domain. SFPQ and NONO are involved in all steps of post-transcriptional regulation and are primarily located in mammalian paraspeckles: liquid phase-separated, ribonucleoprotein sub-nuclear bodies templated by NEAT1 long non-coding RNA. A combination of structured and low-complexity regions provide polyvalent interaction interfaces that facilitate homo- and heterodimerisation, polymerisation, interactions with oligonucleotides, mRNA, long non-coding RNA, and liquid phase-separation, all of which have been implicated in cellular homeostasis and neurological diseases including neuroblastoma.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on understanding the stigma faced by MSM with HIV, transgender women with HIV, and healthcare providers in Dominican Republic healthcare settings.
- Data was collected through focus groups and interviews, identifying four primary stigma themes: migrant stigma, religious stigma, SGM stigma, and HIV stigma.
- The results highlight the severe impact of stigma on mental health, suggesting that effective interventions should tackle both structural barriers and cultural norms that contribute to stigma in HIV care.