Publications by authors named "C Boisseau"
Article Synopsis
- Neutrophil subsets with regulatory properties are often seen as harmful to immune responses against tumors and infections, but new findings suggest otherwise in cases of severe viral respiratory infections (VRI).
- A significant population of neutrophils expressing programmed death-ligand 1 (PD-L1) was identified in humans and mice with VRI, exhibiting strong regulatory functions but diminished antimicrobial capabilities.
- Depleting these PD-L1 neutrophils or blocking their function during VRI led to worse outcomes, indicating that they play a crucial role in managing inflammation and could be potential targets for future treatments.
Synergy between and anti-PcrV antibody delivered in the airways to boost protection against .
Mol Ther Methods Clin Dev
December 2024
Therapeutic antibodies (Ab) have revolutionized the management of multiple illnesses including respiratory tract infections (RTIs). However, anti-infectious Ab displayed several limitations including antigen restrictiveness, narrowed therapeutic windows, and limited dose in the vicinity of the target when delivered by parenteral routes. Strategies enhancing further Ab-dependent containment of infection are currently needed.
View Article and Find Full Text PDFIn everyday life, humans perform sequences of tasks. These tasks may be disrupted in people with obsessive-compulsive disorder (OCD). Symptoms, such as compulsions, can be considered sequential and often cause repetitions of tasks that disrupt daily living (e.
View Article and Find Full Text PDFBackground: Personality disorders (PDs) are often comorbid with obsessive-compulsive disorder (OCD) which may influence symptom presentation and course. This investigation sought to examine the impact of comorbid PDs on clinical presentation and symptom chronicity in a large, prospective longitudinal OCD study.
Methods: Participants (n = 263) were treatment-seeking adults with a primary diagnosis of OCD separated into two groups: individuals with and without a co-occurring PD.
The relationship between obsessive-compulsive disorder symptom subtypes and social adjustment.
J Obsessive Compuls Relat Disord
July 2023
Background: Although it has been widely established that poor social functioning is a characteristic of obsessive-compulsive disorder (OCD), little research has examined the relationship between OCD symptom subtypes and domains of social functioning. Thus, the present study sought to examine the specific ways in which impairment in social adjustment occurs in each symptom subtype of OCD.
Methods: A total of 325 adult participants with a primary diagnosis of OCD were included in the study.