Publications by authors named "C Bobin-Dubigeon"

Background/objectives: Nearly 10% of cancers could be prevented through dietary changes. In addition, breast cancer (BC) is the most common cancer in women worldwide. Inadequate diet may lead to several metabolic abnormalities, including metabolic syndrome (MS).

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Article Synopsis
  • Osteosarcoma (OS) is a rare and aggressive bone cancer with a complex genetic and cellular makeup, and survival rates have remained stagnant for 40 years despite advances in treatment.
  • The study investigated the role of lipopolysaccharide (LPS)-binding protein (LBP) in OS biopsies, finding higher LBP levels in local disease compared to metastatic cases, indicating the possible involvement of Gram-negative bacteria.
  • The findings suggest that the microbiome associated with OS could be crucial for developing new therapies aimed at improving treatment outcomes based on the tumor microenvironment.
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According to the International Agency for Research on Cancer (IARC) more than 10% of cancers can be explained by inadequate diet and excess body weight. Breast cancer is the most common cancer affecting women. The goal of our study is to clarify the relationship between ω3 fatty acids (FA) carried by different lipoproteins and breast cancer (BC) severity, according to two approaches: through clinic-biological data and through in vitro breast cancer cell models.

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Plasma lipids are carried within lipoproteins with various apolipoprotein content. This study evaluates the interest of measuring the apolipoproteins of circulating lipoproteins in breast cancer. Patients with early-stage breast cancer ( = 140) were included.

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Live-pathogenic bacteria, which were identified inside tumors hundreds year ago, are key elements in modern cancer research. As they have a relatively accessible genome, they offer a multitude of metabolic engineering opportunities, useful in several clinical fields. Better understanding of the tumor microenvironment and its associated microbiome would help conceptualize new metabolically engineered species, triggering efficient therapeutic responses against cancer.

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