[Measurement of cardiac output by CO2 rebreathing technique. A study of reproducibility in the normal subject; application to cardiac insufficiency].

A feasibility and reproducibility study of cardiac output measurement by CO2 rebreathing was performed in normal subjects and in patients with compensated cardiac failure. The measurements were performed at rest and at the second stage of the Bruce protocol in normal subjects (N = 12) with a good reproducibility (r = 0.81) after an interval of two days.

[Return to work after myocardial infarction: evaluation and decision].

Working capacity after myocardial infarction depends on the physical and cardiovascular status, psychological repercussions and conditions of work. The latter two are much more important than the first two factors. Cardiovascular functional status is readily assessed by the large number of available investigations which leave little unknown.

Histamine as a ligand in blood plasma. Part 7. Malate, malonate, maleate and tartrate as adjuvants of zinc to favour histamine tissue diffusion through mixed-ligand coordination. In vitro tests on lymphocyte proliferation.

Investigations based on computer simulated distributions of histamine in blood plasma were recently devoted to the assessment of the roles of cysteine, aspartic and glutamic acids as possible adjuvants of zinc to favour histamine tissue diffusion through mixed-ligand coordination. Since all tissues contain at least one of the two enzymes required for the catabolism of histamine, any increase of its tissue diffusion is expected to result in an acceleration of its degradation, which may be of interest for the treatment of anaphylactic disorders. As an extension of these studies, the present paper first reports (i) an experimental investigation of the tendency of four dicarboxylic acids, namely malate, malonate, tartrate and maleate, to mixed-ligand coordination with zinc and histamine, (ii) computer-based potential effects to be expected from the association of these agents to zinc with respect to histamine tissue diffusion.