Improvement in edema and cognitive recovery after moderate traumatic brain injury with the neurosteroid prodrug NTS-104.

Neuroactive steroids reduce mortality, decrease edema, and improve functional outcomes in preclinical and clinical traumatic brain injury (TBI) studies. In this study, we tested the efficacy of two related novel neuroactive steroids, NTS-104 and NTS-105, in a rat model of TBI. NTS-104 is a water-soluble prodrug of NTS-105, a partial progesterone receptor agonist.

NTS-105 decreased cell death and preserved long-term potentiation in an in vitro model of moderate traumatic brain injury.

Traumatic brain injury (TBI) is a major cause of hospitalization and death. To mitigate these human costs, the search for effective drugs to treat TBI continues. In the current study, we evaluated the efficacy of the novel neurosteroid, NTS-105, to reduce post-traumatic pathobiology in an in vitro model of moderate TBI that utilizes an organotypic hippocampal slice culture.

Phase-Assisted Tailored Conductivity of Doped Ceria Electrolytes to Boost SOFC Performance.

Efforts to lower the operating temperature of solid oxide fuel cells include producing electrolytes that are sufficiently conductive and stable below 600 °C. Doped ceria is one such electrolyte being considered. During this study, codoped ceria powders (CeSmMO, M = Bi, Zn and = 0, 0.

The impact of university STEM assets: A systematic review of the empirical evidence.

Background: Innovation ecosystems are an important driver of regional economic growth and development. STEM assets connected to universities may play an important role in such ecosystems.

Objective: To systematically review the literature relating to the effect of university STEM assets on regional economies and innovation ecosystems, providing a better understanding of how the impact is generated and constrained, as well as identifying any gaps in knowledge.

Robust Arduino controlled spin coater using a novel and simple gravity chuck design.

Spin coaters offer an invaluable method of thin film fabrication. Various implementations, both proprietary and open-source exist, offering vacuum and gravity samples chucks. These implementations vary in their reliability, ease-of-use, cost, and versatility.