Publications by authors named "C Biasinutto"
Article Synopsis
- - Hormonal doping, particularly in recreational bodybuilding, poses a public health risk, prompting efforts by WADA to create the Athlete Biological Passport for monitoring doping patterns.
- - A study of 92 male bodybuilders found that 43% reported regular hormone abuse, linking it to lower HDL-cholesterol levels and higher liver enzyme markers compared to controls.
- - Findings indicate that insulin and growth hormone abuse leads to notable metabolic changes, highlighting the need for further research on the long-term effects of these practices.
Cardiovascular disease (CVD) is still a leading cause of morbidity and mortality, despite all the progress achieved as regards to both prevention and treatment. Having high levels of lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease that operates independently. It can increase the risk of developing cardiovascular disease even when LDL cholesterol (LDL-C) levels are within the recommended range, which is referred to as residual cardiovascular risk.
View Article and Find Full Text PDFThe A adenosine receptor is an interesting target whose role in cancer is controversial. In this work, a structural investigation at the 2-position of the [1,2,4]triazolo[1,5-c]pyrimidine nucleus was performed, finding new potent and selective A adenosine receptor antagonists such as the ethyl 2-(4-methoxyphenyl)-5-(methylamino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxylate (20, DZ123) that showed a K value of 0.47 nM and an exceptional selectivity profile over the other adenosine receptor subtypes.
View Article and Find Full Text PDFArticle Synopsis
- Hyperlipidemia significantly contributes to cardiovascular issues, and statins are the primary treatment for managing cholesterol levels and preventing heart disease.
- Patient adherence to statin therapy is often low due to side effects like statin-associated muscle symptoms (SAMS), which can range from mild pain to severe complications like rhabdomyolysis.
- Identifying SAMS is challenging as there is no standard diagnostic test, but various patient risk factors and medication interactions can heighten the likelihood of these muscle-related side effects.
Objective: The aim of our study was to evaluate the prevalence of photosensitivity in SLE as defined by either clinical or laboratory assessment, the concordance of findings obtained by two methods, and the relationship between photosensitivity and clinical and immunological parameters.
Methods: Forty-four SLE patients and 31 healthy subjects were included. Patients and controls underwent a standard questionnaire testing and the minimal erythemal dose (MED) measurement performed by Dermalight-Blue Point.