Two-dimensional organic materials are mainly constructed by using orthogonal anisotropic connectivity of covalent bonding and π-π stacking. The noncovalent connectivity between building blocks is presumed to be too delicate to stabilize the two-dimensional (2D) layers. Contrary to this assumption, we constructed graphite-like 2D layered material by utilizing pure noncovalent connectivity, i.
View Article and Find Full Text PDFThis study investigated the effects of ultrasonication (US) and acetic acid treatments on starches extracted from non-conventional sources: elephant foot yam (NES), cassava (NCS) and sweet potato (NSP). The starches underwent ultrasonication at 40°C for 3, 9, and 15 min, followed by acetylation, with native starches used as control. The morphological, physicochemical, and functional properties were comprehensively analyzed.
View Article and Find Full Text PDFThe heart is an important organ that plays a crucial role in maintaining life. Unfortunately, heart disease is one of the major causes of mortality globally. Early and accurate detection can significantly improve the situation by enabling preventive measures and personalized healthcare recommendations.
View Article and Find Full Text PDFThe non-selective toxicity of colchicine remains a major barrier to its development as an anticancer agent. Here, we report a colchicine derivative, 8l, which exhibits potent and selective antiproliferative activity in prostate cancer cells. The present study investigates the impact of stereochemistry at the C10-substituted chiral amine fragment on the biological activity.
View Article and Find Full Text PDFIntroduction: There is a dearth of evidence regarding the global economic burden of ischaemic heart diseases (IHDs). This systematic review aims to synthesise national-level studies worldwide quantifying the economic burden of IHDs from a provider's perspective.
Methods: We searched PubMed, Embase, Cochrane, DARE and EconLit databases from 1 January 2000 to 29 June 2022.