Publications by authors named "C Bhattacharya"
Background And Objective: Mitiperstat (AZD4831) is a novel irreversible oral myeloperoxidase inhibitor in clinical development for heart failure with preserved ejection fraction, metabolic dysfunction-associated steatohepatitis and chronic obstructive pulmonary disease. This study evaluated the pharmacokinetics, safety and tolerability of multiple ascending doses of mitiperstat in healthy male Japanese and Chinese volunteers.
Methods: Three cohorts of eight Japanese participants were randomized to receive once-daily oral doses of mitiperstat 2.
Article Synopsis
- - Urban populations spend over 90% of their time indoors, leading to lower microbiome diversity and potential negative health effects due to chronic low exposure.
- - Current methods for sampling indoor microbiomes face challenges like low DNA yield and inconsistent collection, impacting study repeatability.
- - A new sampling method using polydimethylsiloxane (PDMS) sheets shows significantly higher DNA yields compared to traditional swab protocols, promising better study replicability and efficiency in microbiome research.
Article Synopsis
- - Lipid nanoparticles (LNPs) are an effective way to deliver messenger RNA (mRNA), overcoming challenges associated with traditional viral gene therapy methods, but current LNP technologies still struggle with optimal mRNA release.
- - Researchers developed a new type of ionizable lipid using a simple one-pot reaction, creating 26 different lipids with a special tetrahydropyrimidine (THP) backbone, significantly speeding up the synthesis process.
- - One of the new lipids, named THP1, showed impressive results in delivering mRNA, providing sustained protein expression, low toxicity, and successful gene editing in liver tissues, making it a promising candidate for future mRNA therapeutic applications.
Aims: Mitiperstat is a novel, highly potent myeloperoxidase inhibitor being evaluated in patients with cardio-metabolic disease (phase 2). These patients often have impaired renal function, which may affect mitiperstat pharmacokinetics. This study assessed mitiperstat pharmacokinetics, safety and tolerability in participants with severe renal impairment and normal renal function, to inform inclusion of participants with estimated glomerular filtration rate (eGFR) < 30 mL/min/1.
View Article and Find Full Text PDFModulating the function of immune cells by targeting the cells themselves has become a key strategy in immunotherapy for combating various diseases such as cancer, autoimmune disorders, and infectious ailments. The use of mRNA (mRNA) is a powerful tool for transiently inducing protein expression, which is often used for genetic manipulation. However, its inherent instability and inability to precisely reach target cells necessitate the use of biomaterials for safe and effective delivery.
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