A differential scanning calorimetry study of the interaction of lasalocid antibiotic with phospholipid bilayers.

Interaction of lasalocid sodium salt (Las-Na) with dipalmitoylphosphatidylcholine (DPPC) as a membrane model was investigated by highly-sensitive differential scanning calorimetry (DSC). The insertion properties of the antibiotic were studied both in multilamellar suspensions and unilamellar vesicles, for Las-Na/DPPC molar ratios (r) ranging from 0.005 to 0.

Lasalocid and biomimetic membranes: insertion in Langmuir films of lipids.

The interfacial properties at the water surface of dipalmitoylphosphatidylcholine (DPPC) in monomolecular films containing various concentrations of lasalocid sodium salt (LAS) have been studied in the range from r = 0.005 to 0.1 (r = molar ratio LAS:DPPC).

Demonstration of cell-ricin interaction by electrophoretic light scattering.

Electrophoretic light scattering has been used to investigate the interaction of ricin, a vegetal toxin, with cells. This technique allowed measurements in the presence of free ligand and proved particularly useful for the study of a system with low affinity. The electrophoretic mobility of erythrocytes and oligodendrocytes was found equal to 2.

Control of ciliary beat by calcium: the effects of lindane, a potent insecticide.

The ciliary beat and cell motility of Dunaliella, a biflagellate unicellular green alga, have been studied by means of computer analysis of high-speed microcinematography and laser doppler velocimetry. Lindane was found rapidly to inhibit cell velocity in less than 5 min. and in a dose-related manner.