Publications by authors named "C Bernick"
Former American football players are at risk for developing traumatic encephalopathy syndrome (TES), the clinical disorder associated with neuropathologically diagnosed chronic traumatic encephalopathy (CTE). The objective of this study was to determine whether hyposmia is present in traumatic encephalopathy syndrome. The study included 119 former professional American football players, 60 former college football players, and 58 same-age asymptomatic unexposed men from the DIAGNOSE CTE Research Project.
View Article and Find Full Text PDFIntroduction: Progression to Alzheimer's disease (AD) dementia from normal cognition (NC) can follow different trajectories, with most progressing through a recognizable mild cognitive impairment stage (NC-MCI-AD), while some individuals transition quickly from NC to AD dementia (NC-AD).
Methods: We compared demographic characteristics, health factors, and cognitive and functional assessments across three time points: the first NC visit, the last NC visit, and the first AD dementia visit.
Results: The NC-MCI-AD group showed greater impairment in cognitive and functional scores at AD dementia diagnosis, despite maintaining better cognitive function during the NC stage.
Article Synopsis
- - Blood-based biomarkers are being explored to detect brain injuries from repetitive head impacts, specifically in former football players, by analyzing plasma levels of various proteins like tau and amyloid.
- - A study involving 180 former football players and 60 control participants found that specific biomarkers (p-tau181 and p-tau231) were significantly elevated in the football players, indicating potential brain damage linked to their sport.
- - The findings suggest that certain plasma proteins (p-tau, GFAP, NfL) could help in understanding and identifying neurological issues related to head impacts, with younger players showing more severe biomarker changes.
Background: Boxing exposes fighters to head impacts and potential traumatic brain injury (TBI). Though research has explored the neuropsychiatric consequences of contact sports, there is limited research into Excessive Daytime Sleepiness (EDS) and its relationship to other outcomes, such as impulsiveness and depression. Therefore, this study aimed to describe EDS in retired boxers using the Epworth Sleepiness Scale (ESS) and to examine how boxing and sleepiness relate to impulsiveness and depression symptomatology.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between perivascular space (PVS) volume in the brain and lifetime exposure to repetitive head impacts (RHI) in individuals at risk for neurodegenerative diseases, particularly focusing on former American football players.
- Conducted across four US study sites from 2016 to 2020, the research involved 224 participants, including 170 former football players and 54 control participants, with analyses exploring how PVS volume correlates with cognitive impairment.
- Results showed that former football players exhibited larger PVS volumes compared to the control group, suggesting that RHI exposure could contribute to changes in brain structure associated with neurodegeneration.