Publications by authors named "C Berndt"
Selenium-dependent glutathione peroxidase 4 (GPX4) is the guardian of ferroptosis, preventing unrestrained (phospho)lipid peroxidation by reducing phospholipid hydroperoxides (PLOOH). However, the contribution of other phospholipid peroxidases in ferroptosis protection remains unclear. We show that cells lacking GPX4 still exhibit substantial PLOOH-reducing capacity, suggesting a contribution of alternative PLOOH peroxidases.
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- Glioblastoma (GBM) is a highly aggressive brain tumor, with a subtype called mesenchymal (MES-GBM) known for its resistance to treatment.
- Trihexyphenidyl (THP), an existing medication, has been shown to effectively inhibit the growth and survival of MES-GBM cells while sparing non-tumor cells.
- The study suggests THP's potential for repurposing as a cancer treatment, but more research is needed to clarify its mechanisms of action and establish optimal treatment protocols.
Article Synopsis
- Ferroptosis is a key form of cell death linked to various diseases, characterized by excessive peroxidation of fatty acids in cell membranes, which causes the cell to rupture.
- This process is influenced by iron and redox balance within cells but can also be targeted for pharmacological treatments, making ferroptosis-related proteins potential candidates for new therapies.
- A research consortium in Germany, along with leading experts, aims to review the mechanisms, significance, and methodologies related to ferroptosis to promote further research and potential new treatments for diseases affected by this process.
Background: Studies have shown improvement in overall survival with anti-PD1/PD-L1 molecules in combination with cisplatin/carboplatin and etoposide as a first-line treatment for Small Cell Lung Cancer (SCLC). However, first-line efficacy remains limited and well below that observed in Non-Small Cell Lung Cancer (NSCLC). Etoposide may have a detrimental effect on lymphocyte activation, which could explain the limited benefit of immunotherapy in the first line and the lack of benefit in the second line for patients previously exposed to high levels of etoposide.
View Article and Find Full Text PDFBackground: Redox control seems to be indispensable for proper embryonic development. The ratio between glutathione (GSH) and its oxidized disulfide (GSSG) is the most abundant cellular redox circuit.
Methods: We used zebrafish harboring the glutaredoxin 1-redox sensitive green fluorescent protein (Grx1-roGFP) probe either in mitochondria or cytosol to test the hypothesis that the GSH:GSSG ratio is strictly regulated through zebrafish embryogenesis to sustain the different developmental processes of the embryo.