Publications by authors named "C Belon"
Introduction: There is controversy surrounding the association between caudal block and complication rates after hypospadias repair. Conflicting results have been reported mostly from single-center, low volume studies and those that did not include relevant variables.
Objectives: We hypothesized that caudal block is not associated with increased rates of reoperation after primary repair and is associated with more complex hypospadias surgery.
Background: Caudal block, the most common regional anesthetic in children, is predominantly performed using palpation to determine placement. The efficacy of the palpation technique is unknown with respect to block success. While ultrasound has been suggested for use during caudal block, its use is infrequent.
View Article and Find Full Text PDFArticle Synopsis
- Mycobacterium abscessus is a growing threat to cystic fibrosis patients due to its resistance to current treatments and potential for causing severe pulmonary and skin infections.
- Research identified a virulence factor, MgtC, that plays a role in the bacteria's survival inside immune cells and can be targeted for new therapies.
- Immunizing with MgtC DNA showed promising results in mouse models, suggesting it could help create effective treatments by stimulating the immune response against M. abscessus infections.
Intramacrophage Survival for Extracellular Bacterial Pathogens: MgtC As a Key Adaptive Factor.
Front Cell Infect Microbiol
January 2018
Background: The MgtC virulence factor has been proposed as an attractive target for antivirulence strategies because it is shared by several important bacterial pathogens, including Salmonella enterica and Mycobacterium tuberculosis (Mtb).
Aim: A natural antagonistic peptide, MgtR, which interacts with MgtC and modulates its stability, has been identified in Salmonella, and we investigated its efficiency to target MgtC in another pathogen.
Materials & Methods: We evaluated the interaction between Salmonella MgtR peptide and the Mtb MgtC protein using an in vivo bacterial two-hybrid system and we addressed the effect of exogenously added synthetic MgtR and endogenously expressed peptide.