Publications by authors named "C Bellevicine"
Introduction: The aim of this project is to assess interobserver agreement for programmed death-ligand 1 (PD-L1) scoring on of non-small cell lung cancer (NSCLC) on cytological specimens in a large-scale multicenter study, by exploiting the cell block-derived tissue microarray (cbTMA) approach.
Methods: A total of 65 cell blocks (CB) diagnosed as NSCLC were retrospectively collected and selected for TMA preparation. Hematoxylin-eosin and PD-L1 stained slides were digitized and uploaded on a free web sharing platform.
Interventional cytopathologist perspective on the Milan System Classification: a study on 929 consecutive salivary gland fine-needle aspirations with a focus on challenging diagnostic categories.
Pathologica
December 2024
Background: Although the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has improved the diagnosis and management of salivary gland lesions, determining the risk of malignancy (ROM) for AUS and SUMP categories remains challenging. We investigated the role of interventional cytopathologists in refining the differential diagnosis of these categories.
Methods: We searched for salivary gland fine-needle aspirations (FNAs) performed at our Institution since the publication of the first edition of MSRSGC.
Objective: ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations represent fundamental predictive biomarkers for advanced non-small cell lung cancer (NSCLC) patients to ensure the best treatment choice. In this scenario, RNA-based NGS approach has emerged as an extremely useful tool for detecting these alterations. In this study, we report our NGS molecular records on ALK, ROS1, NTRK, and RET gene fusions and MET exon 14 skipping alterations detected by using a narrow RNA-based NGS panel, namely SiRe fusion.
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- Giacomo Torno was born in Naples in 1539 or 1541 and became a member of the Clerics Regular Theatines at 18, being welcomed on October 30, 1558.
- He suffered a stroke on December 4, 1608, and experienced torment during his illness, characterized by spasms and discomfort, leading to his death 45 days later.
- Analysis of his mummified body revealed a skin discontinuity at the sacrum, suggesting a wound that occurred during his life, which has been linked to the first recorded instance of the Kennedy terminal ulcer.
Article Synopsis
- Fine needle cytology (FNC) is an important method for differentiating between benign and malignant lymph node conditions due to its low invasiveness, affordability, and high accuracy.
- Proper management of the samples collected during the procedure is crucial for achieving the best diagnostic results, particularly through careful examination of the cellular structures.
- The text discusses a specific pattern called 'concentric ovals distribution,' often seen in benign lymph nodes, which can help cytopathologists accurately diagnose reactive hyperplasia.