The Dual Targeting of FcRn and FcγRs Monomeric Fc Fragments Results in Strong Inhibition of IgG-Dependent Autoimmune Pathologies.

Novel molecules that directly target the neonatal Fc receptor (FcRn) and/or Fc gamma receptors (FcγRs) are emerging as promising treatments for immunoglobulin G (IgG)-dependent autoimmune pathologies. Mutated Fc regions and monoclonal antibodies that target FcRn are currently in clinical development and hold promise for reducing the levels of circulating IgG. Additionally, engineered structures containing multimeric Fc regions allow the dual targeting of FcRn and FcγRs; however, their tolerance needs to first be validated in phase I clinical studies.

Salinity differently affects antioxidant content and amino acid profile in two cultivars of Amaranthus cruentus differing in salinity tolerance.

Background: Amaranthus cruentus is a promising leafy vegetable with high nutritional value and is able to cope with salt stress but the impact of sodium chloride (NaCl) on its main properties have not been studied in detail. Plants from two contrasting cultivars (Rouge: salt-tolerant and Locale: salt-sensitive) were exposed to NaCl (0, 30, 60 and 90 mmol L ) in nutrient solution for 2 weeks. Plant growth, mineral content, oxidative status and antioxidant concentration, salicylic acid concentration, protein content and amino acid profile were analyzed in the harvested leaves.

Fc Sialylation Prolongs Serum Half-Life of Therapeutic Antibodies.

The long serum of IgGs is ensured by their interaction with the neonatal Fc receptor (FcRn), which salvages IgG from intracellular degradation. Fc glycosylation is thought not to influence FcRn binding and IgG longevity in vivo. In this article, we demonstrate that hypersialylation of asparagine 297 (N297) enhances IgG serum persistence.

Improved in vitro and in vivo activity against CD303-expressing targets of the chimeric 122A2 antibody selected for specific glycosylation pattern.

Plasmacytoid dendritic cells (pDCs) play a central role for both innate and adaptive antiviral responses, as they direct immune responses through their unique ability to produce substantial concentrations of type I interferon (IFNs) upon viral encounter while also activating multiple immune cells, including macrophages, DCs, B, natural killer and T cells. Recent evidence clearly indicates that pDCs also play a crucial role in some cancers and several auto-immune diseases. Although treatments are currently available to patients with such pathologies, many are not fully efficient.

[Evaluation of postoperative analgesia with continuous iliofascial nerve sheath block after total hip arthroplasty replacement: a pilot study].

Objective: To assess the analgesic efficiency of a continuous iliofascial nerve sheath block after total hip arthroplasty replacement (RPTH).

Study Design: open and prospective pilot study.

Patients And Methods: Before induction of general anaesthesia (GA), an iliofascial catheter was inserted (group KT, n = 11) or not (group NKT, n = 10).