Diffusion time effects over the adult lifespan indicates persistent zone-specific microstructural alterations in the human prostate with aging.

Purpose: The purpose of this study was to investigate microstructural changes in the aging adult prostate by comparing the effects of varying diffusion times using diffusion MRI, and to provide an age-related benchmark for future prostate cancer studies.

Methods: The prostates of normal male volunteers (n = 70, 19-69 years) were scanned at 3 T with an oscillating gradient spin echo (OGSE: 6 ms), pulsed gradient spin echo (PGSE: 40 ms) and pulsed gradient stimulated echo (PGSTE: 100 ms), and anatomical T-weighted image. Volume and mean diffusivity (MD) were measured in the peripheral (PZ) and transition zones (TZ), which were assessed versus age.

Integration of patient-oriented research principles in health institutions: a scoping review protocol.

Introduction: In 2011, the Canadian Institutes of Health Research launched a Strategy for Patient-Oriented Research (POR) for healthcare and academic institutions to increase patient participation in health research. POR considers patients and caregivers as partners with scientific investigators, healthcare professionals and administrative decision-makers. As POR becomes a standard worldwide, the how-to, practical aspects of POR integration in healthcare institutions remain uncharted territory.

Reflective Tool on Advanced Access to Support Primary Healthcare Teams: Development and Validation of an Online Questionnaire.

Rationale: Awareness of their standing relative to best practices motivates primary healthcare (PHC) teams to improve their practices. However, gathering the data necessary to create such a portrait is a challenge. An effective way to support the improvement of the practices of PHC teams is to simplify the availability of data portraying aspects of their practices that might need improvement.

Sodium MRI of the skin using a surface coil to investigate and reduce signal loss and bias.

Purpose: The purpose was to improve sodium MRI of human skin using a surface coil and twisted projection imaging with smaller, reshaped voxels.

Methods: Calf skin sodium images were acquired in 14 healthy adults using twisted projection imaging with short TE ˜ 0.1 ms, first with a volume coil and voxels (1.

Proteomics fingerprinting reveals importance of iron and oxidative stress in - interactions.

Introduction: The Gram-positive actinobacterium is the major causal agent of potato common scab. The main pathogenicity factor is thaxtomin A, a phytotoxin that causes atypical cell death, although other secondary metabolites have been described to play a role in virulence. Despite this, many aspects of the interaction between and its primary host L.