Publications by authors named "C Beaudreault"
Article Synopsis
- - The review discusses how cell-based therapies using induced pluripotent stem cell-derived inhibitory interneurons are progressing in clinical trials for drug-resistant epilepsy, based on previous successes in treating Parkinson's and Huntington's diseases but faces challenges like graft rejection and the need for immunosuppressive therapy.
- - It evaluates evidence related to human leukocyte antigen (HLA) and explores five approaches to improve cell-based therapies, including autologous transplantation, in vivo reprogramming, and using hypoimmunogenic cells to reduce immune rejection risks.
- - The findings highlight that while early successes in other central nervous system disorders are promising, achieving effective and safe cell-based therapies for epilepsy will require addressing immunogenicity and complications associated with surgical techniques.
Article Synopsis
- - The case study discusses a 24-year-old male with tuberous sclerosis complex (TSC) who achieved significant seizure control after receiving a responsive neurostimulation (RNS) device, despite it being generally regarded as a palliative option for drug-resistant epilepsy (DRE).
- - Before the RNS implantation, the patient underwent multiple surgical procedures and treatments but continued to experience frequent seizures. Initially, the RNS reduced his seizures, but after a lead revision, he became seizure-free for nearly 3 years, with only a couple of breakthrough seizures later on.
- - The findings suggest that RNS could be an effective treatment for epilepsy in TSC patients when other treatments have failed, indicating that this therapy should be
Background And Objectives: Although ventriculoperitoneal (VP) shunts are a common treatment for hydrocephalus, there are complication risks including infections. Late complications such as ventriculitis from ascending abdominal infections can have severe consequences. However, the incidence of central nervous system (CNS) infections in VP shunt patients with abdominal infections is not well understood.
View Article and Find Full Text PDFObjective: To assess the impact of vagus nerve stimulation (VNS) on quality of life contributors such as rescue medications.
Methods: Using the seizure diary application SeizureTracker™ database, we examined trends in rescue administration frequency before and after the first recorded VNS magnet swipe in patients with drug-resistant epilepsy who had 1) At least one VNS magnet swipe recorded in the diary, and 2) Recorded usage of a benzodiazepine rescue medication (RM) within 90 days prior to the first swipe. A paired Wilcoxon rank-sum test was used to assess changes in RM usage frequency between 30-, 60-, 90-, 180- and 360-day intervals beginning 30 days after first magnet swipe.
Purpose: To assess responsive neurostimulation (RNS) efficacy in pediatric patients with drug-resistant epilepsy, comparing response (≥ 50% reduction in seizure frequency) rates between patients with two or fewer seizure foci and those with multifocal or generalized epilepsy. This study seeks to address the gap in knowledge regarding RNS effectiveness in pediatric populations.
Methods: A systematic review and meta-analysis included data from PubMed, Embase, and Web of Science through November 2023, including 17 retrospective studies and a case series of 24 patients from our practice for a total of 105 aggregated patients.