Publications by authors named "C Basagni"
Background: Carbapenem-resistant Enterobacterales, particularly those producing carbapenemases (CPE), pose a major threat to human health, being listed among critical-priority resistant pathogens by the World Health Organization.
Aim: In this study we report on a large nosocomial spread of CPE of different species producing VIM-type carbapenemases, and on the infection prevention and control measures thata were adopted to contrast the spread.
Methods: Conventional culture and molecular methods were used for detection and identification of VIM-positive CPE (VIM-CPE) causing infections or colonizing patients or present in environmental specimens.
Article Synopsis
- Acute bronchiolitis is a major cause of lower respiratory infections and hospitalizations in children under one year old, prompting a study at the Teaching Hospital in Siena, Italy.
- A retrospective study analyzed 36,031 pediatric ED visits from September 2018 to April 2023, identifying 383 cases of bronchiolitis, which were more frequent in younger children and associated with higher admission rates based on severity.
- The findings suggest implementing better collaboration between hospital services and community care to ensure timely diagnoses and reduce unnecessary ED visits for mild cases of bronchiolitis.
Article Synopsis
- Fluoroquinolones (FQs) are important antibiotics, but their usage has decreased due to ecological concerns and side effects, prompting antimicrobial stewardship programs (ASP) aimed at reducing their consumption.
- A 700-bed teaching hospital implemented an ASP in January 2021, which included monitoring antibiotic consumption, mandatory prescription motivation targeting over 75% motivation, and training on FQs usage.
- The intervention led to a 6.6% overall decrease in antibiotic use and a significant 48.3% reduction in FQs consumption, indicating that a straightforward ASP approach can effectively achieve targets for reducing antibiotic usage.
Genome-wide association studies identified over 200 risk loci for multiple sclerosis (MS) focusing on common variants, which account for about 50% of disease heritability. The goal of this study was to investigate whether low-frequency and rare functional variants, located in MS-established associated loci, may contribute to disease risk in a relatively homogeneous population, testing their cumulative effect (burden) with gene-wise tests. We sequenced 98 genes in 588 Italian patients with MS and 408 matched healthy controls (HCs).
View Article and Find Full Text PDFBackground: Multiple Sclerosis (MS) is a chronic inflammatory and neurodegenerative demyelinating disease of the central nervous system. It is a complex and heterogeneous disease caused by a combination of genetic and environmental factors, and it can cluster in families.
Objective: to evaluate at gene-level the aggregate contribution of predicted damaging low-frequency and rare variants to MS risk in multiplex families.