Publications by authors named "C Barrionuevo"
Article Synopsis
- Human Herpesviruses (HHVs) are linked to serious neurological diseases like encephalitis and meningitis, presenting a major health challenge, especially for individuals with compromised immune systems such as those with HIV/AIDS.
- A study of 895 patients suspected of having viral CNS infections found that 7.5% tested positive for HHVs, with Cytomegalovirus (HCMV) and Epstein-Barr Virus (EBV) being the most common, emphasizing their role in neurological conditions.
- The findings highlight the importance of analyzing cerebrospinal fluid (CSF) for accurate diagnosis and stress the need for tailored treatment strategies in managing CNS infections, particularly in immunocompromised patients.
Epstein-Barr virus (EBV) is a potent carcinogen linked to hematologic and solid malignancies and causes significant global morbidity and mortality. Therapy using allogeneic EBV-specific lymphocytes shows promise in certain populations, but the impact of EBV genome variation on these strategies remains unexplored. To address this, we sequenced 217 EBV genomes, including hematologic malignancies from Guatemala, Peru, Malawi, and Taiwan, and analyzed them alongside 1307 publicly available EBV genomes from cancer, nonmalignant diseases, and healthy individuals across Africa, Asia, Europe, North America, and South America.
View Article and Find Full Text PDFBackground: Central nervous system (CNS) infections are important causes of mortality and morbidity in children, and they are related to severe problems such as hearing loss, neurological sequelae, and death. The objective was to describe clinical and laboratory exam profiles of children who were diagnosed with CNS infections.
Methods: We conducted a cross-sectional study based on medical records, which included pediatric patients aged from 3 months to 15 years, with a clinical suspicion of CNS infection between January 2014 to December 2019.
Rifampicin is a potent antimicrobial drug with some suboptimal properties, such as poor stability, low solubility, and variable bioavailability. Therefore, in the current study, a multicomponent complex between rifampicin, γ-cyclodextrin, and arginine was prepared with the aim of improving drug properties. Solubility was evaluated by phase-solubility studies.
View Article and Find Full Text PDFArticle Synopsis
- * The transcription factor GATA-3 plays a crucial role in T-cell development and has been linked to the most common mature T-cell lymphoma in the Western world, acting as a proto-oncogene in various T-cell neoplasms.
- * Findings suggest that GATA-3-dependent transcriptional programs could be targeted for therapy, particularly since GATA-3 driven T-cell neoplasms often have poor outcomes, indicating a potential for improved treatment strategies.