Comparative Effectiveness of Lurbinectedin for the Treatment of Relapsed Small Cell Lung Cancer in the Post-Platinum Setting: A Real-World Canadian Synthetic Control Arm Analysis.

Background: Based on findings from a single-arm, phase 2 basket trial (NCT02454972), lurbinectedin may be an effective treatment for individuals with small cell lung cancer (SCLC) who progressed on or after platinum-based chemotherapy.

Objective: To estimate the comparative effectiveness of lurbinectedin versus the historical standard of care for relapsed SCLC in Canada.

Methods: A synthetic control arm (SCA) analysis was conducted using real-world data.

Biomechanical Sequelae of Syndesmosis Injury and Repair.

This review characterizes fibula mechanics in the context of syndesmosis injury and repair. Through detailed understanding of fibula kinematics (the study of motion) and kinetics (the study of forces that cause motion), the full complexity of fibula motion can be appreciated. Although the magnitudes of fibula rotation and translation are inherently small, even slight alterations of fibula position or movement can substantially impact force propagation through the ankle and hindfoot joints.

Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster.

Background: SPARC is a collagen-binding glycoprotein whose functions during early development are unknown. We previously reported that SPARC is expressed in Drosophila by hemocytes and the fat body (FB) and enriched in basal laminae (BL) surrounding tissues, including adipocytes. We sought to explore if SPARC is required for proper BL assembly in the FB.

P300 latency, but not amplitude or topography, distinguishes between true and false recognition.

Two experiments are described in which the P300 component of the event-related potential was recorded during a modification of the Deese-Roediger-McDermott false-memory paradigm. P300 amplitudes and topographies were evaluated in both true recognition of previously presented (studied) words and in false recognition of associatively related, never presented (critical lure) words. P300 topography and amplitude did not appear to differ between true and false recognition.

Participants in HIV clinical trials in Europe.

In recent years an increasing number of antiretrovirals have become available. In order to define the optimal treatment regimens an increasing number of clinical trials are needed. Our objective was to study the profile of participants in HIV clinical trials in Europe and learn from their experience and views.