Publications by authors named "C Baptiste"
Purpose Of Review: Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disorder predominantly affecting individuals of Mediterranean and Middle Eastern descent, including those with certain heritages including Sephardic Jewish, Armenian, Turkish, and Arab. The disorder affects up to 1 in 200 people making it a very common etiology for pain states worldwide, including serositis mediated painful states of the chest, joint, and abdomen.
Recent Findings: Defined by recurrent episodes of fever and inflammation, FMF can lead to not only severe pain, but complications such as renal amyloidosis, if untreated.
The clinical implications of placental chromosomal mosaicism can be challenging for patients and health care providers. Key considerations include the specific characteristics of the chromosomal abnormality (such as size, gene content, and copy number), the timing of the mosaicism's onset during embryogenesis or fetal development, the types of tissues involved, and the level of mosaicism (the ratio of normal to abnormal cells within those tissues). Genetic counseling can help inform patients about the chances of having a live-born child with a chromosomal abnormality.
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- The study focuses on early preterm infants who are small for gestational age (SGA) and examines the role of genetic disorders in their high rates of morbidity and mortality.
- Researchers conducted a retrospective analysis of infants born between 2000-2020, comparing the prevalence of genetic disorders in SGA infants (with and without congenital anomalies) to those who were appropriate for gestational age (AGA).
- Findings revealed that genetic disorders were identified in a small percentage of SGA infants, with trisomies 13, 18, and 21 being the most common, highlighting the need for further research on genetic factors contributing to their health outcomes.
The development of synthetic bone substitutes that equal or exceed the efficacy of autologous graft remains challenging. In this study, a rat calvarial defect model was used as a reference to investigate the influence of composition and architecture of 3D-printed cement, with or without bioactives, on tissue regeneration. Printable cement pastes were formulated by combining hyaluronic acid and cement precursors.
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- The study focuses on the outcomes of patients who experience pre- and periviable preterm premature rupture of membranes (pPPROM) after fetoscopic laser surgery (FLS) for twin-twin transfusion syndrome (TTTS).
- It analyzed data from 171 FLS cases, finding that 18.8% of 96 included subjects experienced pPPROM, with significant differences in dual survivorship and perinatal outcomes compared to those without pPPROM.
- Despite lower gestational age and survival rates for twins among those with pPPROM, the survival rate to live birth of at least one twin remained high for patients who chose expectant management.