Publications by authors named "C Bandala"
Introduction: CD38 and BCMA are proteins expressed at high levels in multiple myeloma cells, so they are targets for the development of mono- or multispecific antibodies.
Areas Covered: Patent US20240132615 describes anti-CD3/BCMA/CD38 trispecific antibodies and a method of treating relapsed/refractory multiple myeloma pharmaceutically. and preclinical results show that anti-CD3/BCMA/CD38 trispecific antibodies have stronger binding affinity and killing potency compared to daratumumab, isatuximab, and teclistamab antibodies.
Article Synopsis
- * Dysregulation of tryptophan (Trp) metabolism plays a role in FM, as Trp is crucial for serotonin production and is involved in immune responses via the kynurenine pathway, affecting mood and pain perception.
- * The review suggests a new treatment strategy for FM by inhibiting the synthesis of neurotoxic quinolinic acid (QA) and using selective serotonin reuptake inhibitors to elevate protective kynurenic acid (KYNA) levels, aiming to reduce pain and improve mental health outcomes.
Epilepsy is a disorder characterized by a predisposition to generate seizures. Levetiracetam (LEV) is an antiseizure drug that has demonstrated oxidant-antioxidant effects during the early stages of epilepsy in several animal models. However, the effect of LEV on oxidant-antioxidant activity during long-term epilepsy has not been studied.
View Article and Find Full Text PDFBreast cancer (BCa) is related to chronic stress and can reduce the bone mineral density (BMD) through neurochemicals related to beta-adrenergic receptor (ADRB) 1 and 2. Selective beta blockers (sBBs) and nonselective beta blockers (nsBBs) are used to treat systemic arterial hypertension (SAH) and may have osteoprotective effects, as they inhibit ADRBs. To evaluate the effects of sBBs and nsBBs on the BMD of Mexican patients with BCa.
View Article and Find Full Text PDFUnlabelled: (GS) and berberine (BBR) are natural products that have demonstrated therapeutic potential for the management of obesity and its comorbidities, as effective and safe alternatives to synthetic drugs. Although their anti-obesogenic and antidiabetic properties have been widely studied, comparative research on their impact on the gene expression of adipokines, such as resistin (Res), omentin (Ome), visfatin (Vis) and apelin (Ap), has not been reported.
Methodology: We performed a comparative study in 50 adult Mexican patients with obesity treated with GS or BBR for 3 months.