A novel predictive algorithm to personalize autologous T-cell harvest for chimeric antigen receptor T-cell manufacture.

Background Aims: The most widely accepted starting materials for chimeric antigen receptor T-cell manufacture are autologous CD3+ T cells obtained via the process of leukapheresis, also known as T-cell harvest. As this treatment modality gains momentum and apheresis units struggle to meet demand for harvest slots, strategies to streamline this critical step are warranted.

Methods: This retrospective review of 262 T-cell harvests, with a control cohort of healthy donors, analyzed the parameters impacting CD3+ T-cell yield in adults with B-cell malignancies.

Correction: Biological control of the Asian chestnut gall wasp in Portugal: Insights from a mathematical model.

[This corrects the article DOI: 10.1371/journal.pone.

Biological control of the Asian chestnut gall wasp in Portugal: Insights from a mathematical model.

In recent years, the Asian gall wasp Dryocosmus kuriphilus has invaded chestnut trees and significantly affected the Portuguese chestnut production. Studies in other countries, such as Japan or Italy, have shown that the parasitoid Torymus sinensis can successfully achieve biological control of D. kuriphilus.

Computational simulation of the COVID-19 epidemic with the SEIR stochastic model.

A small number of individuals infected within a community can lead to the rapid spread of the disease throughout that community, leading to an epidemic outbreak. This is even more true for highly contagious diseases such as COVID-19, known to be caused by the new coronavirus SARS-CoV-2. Mathematical models of epidemics allow estimating several impacts on the population and, therefore, are of great use for the definition of public health policies.

Hepatitis C in a Mobile Low-Threshold Methadone Program.

Introduction: Data on the epidemiology of hepatitis C among individuals who use drugs in low-threshold settings are lacking, although crucial to assess the burden of disease and aid in the design of treatment strategies.

Objective: The aim of this study was to characterize the epidemiology and disease related to hepatitis C in a population attending a low-threshold methadone program.

Materials And Methods: A cross-sectional study in the population attending the Mobile Low-Threshold Methadone Program in Lisbon, Portugal, was carried out.