Publications by authors named "C Bakoyiannis"
Cardiovascular disease is a major cause of morbidity and mortality worldwide. In the last few years, the role of inflammation and inflammatory modulatory medications is investigated for the optimal treatment of coronary artery disease. It can be hypothesized that since inflammation is also involved in carotid artery stenosis development and progression, the same class of medication could be useful.
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- - The study investigates characteristics that affect successful revascularization in patients with lower extremity chronic total occlusions (CTOs) compared to those with non-CTO stenosis, revealing significant demographic and clinical differences.
- - Among the 256 patients analyzed, those with CTOs showed a higher prevalence of risk factors such as myocardial infarction and end-stage renal disease, while aspirin use predicted better outcomes and a history of malignancy predicted worse outcomes for crossing CTOs.
- - Findings suggest that successful endovascular revascularization is linked to specific baseline clinical variables and the overall health burden in CTO patients, highlighting the complexity of their condition.
Purpose Of Review: Obesity is a significant public health problem and a major risk factor for the development and progression of atherosclerosis and its cardiovascular manifestations. Lower extremity peripheral artery disease (PAD) affects 3%-10% of the Western population and, if left untreated, can lead to devastating outcomes with both an increased risk of morbidity and mortality. Interestingly, the association between obesity and PAD remains debatable.
View Article and Find Full Text PDFAs clinical efforts towards breast-conserving therapy and prolonging survival of those with metastatic breast cancer increase, innovative approaches with the use of biologics are on the rise. Two areas of current focus are cancer immunotherapy and autophagy, both of which have been well-studied independently but have recently been shown to have intertwining roles in cancer. An increased understanding of their interactions could provide new insights that result in novel diagnostic, prognostic, and therapeutic strategies.
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- Anatomical variations in the nasal cavity and sinuses can impact sinus drainage but their link to sinus disease is still debated in the literature.
- The review analyzed 30 studies involving 6,999 patients, revealing mixed results on whether these variations increase the risk of sinus pathology.
- The need for detailed CT assessments in chronic rhinosinusitis cases is emphasized, indicating that further research is required to better understand the relationship between anatomical variations and sinus issues.