Prolonged clot lysis time increases the risk of a first but not recurrent venous thrombosis.

The role of the fibrinolytic system in the development of venous thrombosis (VT) is unclear. We studied the risk of first and recurrent VT associated with reduced fibrinolysis, as measured by clot lysis time (CLT). We also studied the relationship between CLT and thrombin generation to determine if any relationship between CLT and VT was affected by thrombin generation.

The risk of a first and a recurrent venous thrombosis associated with an elevated D-dimer level and an elevated thrombin potential: results of the THE-VTE study.

Background: D-dimer and thrombin generation have been associated with the risk of recurrent venous thrombosis. However, for both measurements, different assays are available, and in vitro thrombin generation may be affected by the problem of contact activation during blood sampling.

Objectives: To determine the association between hypercoagulability and first and recurrent thrombosis by the use of different D-dimer and thrombin generation assays, to assess whether the addition of corn trypsin inhibitor (CTI) prior to blood sampling to inhibit contact activation improved the association between thrombin generation and thrombosis risk, and to calculate the DASH score with two different D-dimer assays.

Self-report and caregiver-report of sleep and psychopathology in children with high-functioning autism spectrum disorder: A pilot study.

Objective: To examine relationships between psychological and sleep problems in children with high-functioning autism spectrum disorder (HFASD) and typically developing (TD) children using self-report and caregiver-report.

Method: Seventeen HFASD (M = 10.03 years, SD = 1.

International clinical practice guidelines for the treatment and prophylaxis of thrombosis associated with central venous catheters in patients with cancer.

Background: Although long-term indwelling central venous catheters (CVCs) may lead to pulmonary embolism (PE) and loss of the CVC, there is lack of consensus on management of CVC-related thrombosis (CRT) in cancer patients and heterogeneity in clinical practices worldwide.

Objectives: To establish common international Good Clinical Practices Guidelines (GCPG) for the management of CRT in cancer patients.

Methods: An international working group of experts was set up to develop GCPG according to an evidence-based medicine approach, using the GRADE system.

International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer.

Background:  Guidelines addressing the management of venous thromboembolism (VTE) in cancer patients are heterogeneous and their implementation has been suboptimal worldwide.

Objectives: To establish a common international consensus addressing practical, clinically relevant questions in this setting.

Methods: An international consensus working group of experts was set up to develop guidelines according to an evidence-based medicine approach, using the GRADE system.