Lessons learned to enable question answering on knowledge graphs extracted from scientific publications: A case study on the coronavirus literature.

The article presents a workflow to create a question-answering system whose knowledge base combines knowledge graphs and scientific publications on coronaviruses. It is based on the experience gained in modeling evidence from research articles to provide answers to questions in natural language. The work contains best practices for acquiring scientific publications, tuning language models to identify and normalize relevant entities, creating representational models based on probabilistic topics, and formalizing an ontology that describes the associations between domain concepts supported by the scientific literature.

Potentially inappropriate medications in older adults living with HIV.

Objectives: We assessed the prevalence of potentially inappropriate medication (PIM) among older (≥ 65 years) people living with HIV (O-PLWH) in the region of Madrid.

Methods: We analysed the dispensation registry of community and hospital pharmacies from the Madrid Regional Health Service (SERMAS) for the period between 1 January and 30 June 2017, looking specifically at PIMs according to the 2019 Beers criteria. Co-medications were classified according to the Anatomical Therapeutic Chemical (ATC) classification system.

Polypharmacy and Drug-Drug Interactions in People Living With Human Immunodeficiency Virus in the Region of Madrid, Spain: A Population-Based Study.

Background: Drug-drug interactions (DDIs) that involve antiretrovirals (ARVs) tend to cause harm if unrecognized, especially in the context of comorbidity and polypharmacy.

Methods: A linkage was established between the drug dispensing registry of Madrid and the Liverpool human immunodeficiency virus (HIV) DDI database (January 2017-June 2017). Polypharmacy was defined as the use of ≥5 non-HIV medications, and DDIs were classified by a traffic-light ranking for severity.