Publications by authors named "C BACH"
Introduction: Angiotensin II may reduce muscle ischemia during intermittent hemodialysis and thereby decrease the incidence and/or intensity of intradialytic muscle cramps. We aimed to test whether angiotensin II infusion during intermittent hemodialysis is safe, feasible, and effective in the attenuation of muscle cramps.
Methods: We performed a pilot, single-blinded, randomized crossover trial of patients receiving intermittent hemodialysis who frequently experience intradialytic muscle cramps.
Article Synopsis
- Developing 3D cell cultures from glioma cell lines can enhance tumor therapy research by mimicking patient tumors more closely than traditional 2D cultures.
- The study focused on optimizing parameters for high-throughput screening, analyzing how initial cell numbers and culture time affect spheroid growth and viability.
- Key findings showed that fewer initial cells led to better growth in spheroids, highlighting the potential for improved testing of treatments like temozolomide and radiation in more representative tumor models.
Recurrent mutations in the CTNNB1 or APC genes leading to the activation of the Wnt/betacatenin pathway are observed in adnexal tumors with matrical differentiation. While most pilomatricomas arise sporadically and harbor CTNNB1 mutations, cutaneous hybrid cysts combining epidermal and matrical differentiations have been mostly reported in a context of the familial adenomatosis polyposis/Gardner's syndrome related to germinal mutations of APC. The objective of this study is to understand the pathogenesis of hybrid cysts combining epidermal and matrical differentiations.
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- Salivary gland Secretory Carcinoma (SC) is a rare tumor first described in 2010; a study analyzed 108 cases from the REFCOR database to evaluate diagnosis, treatment, and survival rates up to July 2021.
- MRI was found to be ineffective for diagnosing malignancy, and while 79% of patients received a diagnosis after two histological readings, 21% needed molecular testing for confirmation.
- Results showed high survival rates, with 91.4% overall survival and 89% recurrence-free survival at five years, suggesting a generally positive prognosis for SC patients.*