Acute Hyperhidrosis: A Clue to Underlying Autonomic Dysfunction and a Rare Neurological Disorder.

Acute hyperhidrosis is characterized by excessive sweating. In the absence of other symptoms, the symptoms of sweating alone are often benign and may be ignored by patients and clinicians. Rarely, hyperhidrosis may be a harbinger of an underlying severe disease.

Development and validation of a short form for the Raven's Coloured Progressive Matrices using a machine learning approach.

Raven's Coloured Progressive Matrices (CPM) is a widely used assessment tool for measuring general cognitive ability in developmental and educational research, particularly in studies involving young children. However, administering the full set of the 36-item CPM can be burdensome for young participants, hindering its practicality in large-scale studies and reducing research efficiency. In the current study, a short form of the CPM was developed based on a sample of preschoolers (n = 336, mean age = 5.

Neighborhood Disadvantage and the Association of Hurricanes Sandy and Harvey With Veterans' Mental Health.

Importance: Hurricanes are associated with a wide range of adverse health effects in the general population and are increasing in frequency and severity due to global climate change. Due to prior military exposures and distinct sociodemographic characteristics, US veterans may be more vulnerable than the general population to negative health effects of hurricanes.

Objective: To evaluate whether acute care mental health visits among US veterans were associated with exposure to hurricanes.

Structure of the human autophagy factor EPG5 and the molecular basis of its conserved mode of interaction with Atg8-family proteins.

The multi-step macroautophagy/autophagy process ends with the cargo-laden autophagosome fusing with the lysosome to deliver the materials to be degraded. The metazoan-specific autophagy factor EPG5 plays a crucial role in this step by enforcing fusion specificity and preventing mistargeting. How EPG5 exerts its critical function and how its deficiency leads to diverse phenotypes of the rare multi-system disorder Vici syndrome are not fully understood.

Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity.

The heterodimeric Rab3GAP complex is a guanine nucleotide exchange factor (GEF) for the Rab18 GTPase that regulates lipid droplet metabolism, ER-to-Golgi trafficking, secretion, and autophagy. Why both subunits of Rab3GAP are required for Rab18 GEF activity and the molecular basis of how Rab3GAP engages and activates its cognate substrate are unknown. Here we show that human Rab3GAP is conformationally flexible and potentially autoinhibited by the C-terminal domain of its Rab3GAP2 subunit.