Publications by authors named "C B Trapnell"
Retinal degeneration in mammals causes permanent loss of vision, due to an inability to regenerate naturally. Some non-mammalian vertebrates show robust regeneration, via Muller glia (MG). We have recently made significant progress in stimulating adult mouse MG to regenerate functional neurons by transgenic expression of the proneural transcription factor Ascl1.
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- Human genetics has evolved significantly over the last 30 years, shifting focus from rare Mendelian diseases to the intricate genetic factors influencing common diseases.
- Researchers highlight the critical role of genetic context—including variants, gene regulation, and environmental interactions—in understanding how these genetic variants impact health.
- The article calls for unified methods to analyze the complex interplay of molecular and environmental factors, proposing that combining cellular, animal, and epidemiological data can enhance our interpretation of genetic variants and improve disease treatment strategies.
Article Synopsis
- * Researchers identified a specific gene, ID1, that plays a critical role in the transformation process by affecting gene expression and the morphology of melanocytes, indicating its contribution to the early stages of melanoma.
- * The study's findings suggest that there are clinically undetectable precursors to melanoma that exhibit distinct traits and that targeting these precursors could lead to improved methods for early diagnosis and prevention of the disease.
Hematopoietic stem cells (HSCs) arise in embryogenesis from a specialized hemogenic endothelium (HE). In this process, HE cells undergo a unique fate change termed endothelial-to-hematopoietic transition, or EHT. While induced pluripotent stem cells (iPSCs) give rise to HE with robust hemogenic potential, the generation of bona fide HSCs from iPSCs remains a challenge.
View Article and Find Full Text PDFSex differences and age-related changes in the human heart at the tissue, cell, and molecular level have been well-documented and many may be relevant for cardiovascular disease. However, how molecular programs within individual cell types vary across individuals by age and sex remains poorly characterized. To better understand this variation, we performed single-nucleus combinatorial indexing (sci) ATAC- and RNA-Seq in human heart samples from nine donors.
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