Publications by authors named "C B THORNE"
Objective: Interstitial lung disease (ILD) is a common and potentially lethal complication of systemic sclerosis (SSc). Screening by high-resolution computed tomography (HRCT) is recommended in all patients with risk factors, including early disease. Little is known on late presentations of ILD.
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- The study aimed to understand nonarticular pain (NAP) in patients newly diagnosed with rheumatoid arthritis (RA), tracking its changes during the first year of treatment and linking it with active inflammation and remission outcomes.
- More than half of the participants (392, mostly female, average age of 56) experienced NAP, with the majority reporting regional pain, which often persisted or worsened over time.
- The results indicated that both regional and widespread NAP were negatively associated with achieving remission, suggesting that addressing NAP is crucial in managing early RA.
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- A survey was conducted among 32 senior clinicians across 20 European countries to understand current practices in postnatal prophylaxis (PNP) and infant feeding guidelines.
- Twenty-three clinicians responded, revealing that all countries use risk stratification for PNP, but methods and regimens widely differ, with zidovudine being the most commonly used drug.
- There is significant variation in guidelines regarding infant feeding for babies born to HIV-positive parents, highlighting the need for harmonization in policies to minimize HIV transmission and support informed feeding choices.
The sudden rise of the SARS-CoV-2 virus and the delay in the development of effective therapeutics to mitigate it made evident a need for ways to screen for compounds that can block infection and prevent further pathogenesis and spread. Yet, identifying effective drugs efficacious against viral infection and replication with minimal toxicity for the patient can be difficult. Monoclonal antibodies were shown to be effective, yet as the SARS-CoV-2 mutated, these antibodies became ineffective.
View Article and Find Full Text PDFCataracts are the world's leading cause of blindness, and diabetes is the second leading risk factor for cataracts after old age. Despite this, no preventative treatment exists for cataracts. The altered metabolism of excess glucose during hyperglycaemia is known to be the underlying cause of diabetic cataractogenesis, resulting in localised disruptions to fibre cell morphology and cell swelling in the outer cortex of the lens.
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