Publications by authors named "C B Shumate"
Background: Birth defects are associated with childhood cancer, but little is known regarding pediatric carcinomas, a group of especially rare tumors.
Methods: We used Cox proportional hazards regression to estimate the hazard ratio (HR) and 95 % confidence interval (CI) for any carcinoma, as well as thyroid, hepatocellular, and renal carcinoma specifically, up to 18 years of age among children with major, non-syndromic anomalies or chromosomal/genetic syndromes, relative to unaffected children.
Results: Our registry-linkage study included nine states and 21,933,476 children between 1990 and 2018: 641,827 with non-syndromic anomalies, and 49,619 with syndromes.
Article Synopsis
- - The study evaluates the effectiveness of the 5-minute Apgar score in predicting neonatal mortality specifically in infants with major birth defects, indicating its substantial predictive capability.
- - Analyzing data from the Texas Birth Defect Registry, researchers found that low Apgar scores (less than 7) were strongly linked to higher mortality rates within the first 28 days of life, even among different defect categories and types of births (preterm and term).
- - The findings suggest that the Apgar score can serve as a valuable tool for quick clinical assessments of newborns with birth defects, but further research is necessary to optimize its use in this group.
To promote safe supplement use, athletes are advised to choose third-party tested (TPT) supplements to minimise doping risk. This study evaluated changes in knowledge on supplements in US high school athletes from a 2-week online supplement education programme. One group of sophomores (ED, n = 48) completed a Canvas course on safe supplement use, based on the Theory of Planned Behaviour, while the other group of freshmen (NOED, n = 38) did not.
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- * Most cases were live births (99%) and predominantly male, with a higher prevalence noted in urban areas and among certain maternal characteristics, such as older age and Non-Hispanic White ethnicity.
- * The research also aimed to identify the most common associated congenital defects in cases that were non-isolated (those not part of a syndrome) to better understand the condition's epidemiology.
Article Synopsis
- - Coloboma is a rare congenital condition where part of the eye's tissue is missing, potentially leading to visual impairments; this study analyzed data from the Texas Birth Defects Registry spanning 1999 to 2014 to better understand its prevalence.
- - The research identified 1,587 coloboma cases, noting that about 58.8% were nonsyndromic, and highlighted key factors affecting prevalence, such as maternal education, race/ethnicity, plurality of births, and maternal diabetes.
- - The findings suggest a rising trend in coloboma cases over the years and could help target screening efforts for at-risk populations, potentially improving outcomes for future children.