Ethical Considerations of Off-Label Prescribing in Disruptive Mood Dysregulation Disorder.

AbstractDisruptive mood dysregulation disorder (DMDD), a relatively new diagnosis in child and adolescent psychiatry that remains without medications approved for its indication, warrants a renewed consideration of the ethics surrounding the off-label use of medications. In the absence of empirical studies, clinicians must work with the best available information regarding treatment, such as case reports demonstrating the success of off-label interventions. Although subject to ethical limitations and the risk-benefit profile of each medication, increased use of this approach in the treatment of DMDD is warranted.

The Psychedelic Future of Post-Traumatic Stress Disorder Treatment.

Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to a traumatic experience. An estimated 12 million U.S.

Multifractal Analysis of a Seismic Moment Distribution Obtained From InSAR Inversion.

Interferometric synthetic aperture radar (InSAR) interferograms contain valuable information about the fault systems hidden beneath the surface of the Earth. In a new approach, we aim to fit InSAR ground deformation data using a distribution of multiple seismic point sources whose parameters are found by a genetic algorithm. The resulting source distribution could provide another useful tool in solving the difficult problem of accurately mapping earthquake faults.

Early childhood fluoride exposure and preadolescent kidney function.

Background: Early-life renal maturation is susceptible to nephrotoxic environmental chemicals. Given the widespread consumption of fluoride and the global obesity epidemic, our main aim was to determine whether childhood fluoride exposure adversely affects kidney function in preadolescence, and if adiposity status modifies this association.

Methods: Our study included 438 children from the PROGRESS cohort.

Reports on progress in physics the complex dynamics of earthquake fault systems: new approaches to forecasting and nowcasting of earthquakes.

Charles Richter's observation that 'only fools and charlatans predict earthquakes,' reflects the fact that despite more than 100 years of effort, seismologists remain unable to do so with reliable and accurate results. Meaningful prediction involves specifying the location, time, and size of an earthquake before it occurs to greater precision than expected purely by chance from the known statistics of earthquakes in an area. In this context, 'forecasting' implies a prediction with a specification of a probability of the time, location, and magnitude.