Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington's disease decades before clinical motor diagnosis.

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease with the age at which characteristic symptoms manifest strongly influenced by inherited HTT CAG length. Somatic CAG expansion occurs throughout life and understanding the impact of somatic expansion on neurodegeneration is key to developing therapeutic targets. In 57 HD gene expanded (HDGE) individuals, ~23 years before their predicted clinical motor diagnosis, no significant decline in clinical, cognitive or neuropsychiatric function was observed over 4.

Key considerations for combination therapy in Alzheimer's clinical trials: Perspectives from an expert advisory board convened by the Alzheimer's drug discovery foundation.

There is growing consensus in the Alzheimer's community that combination therapy will be needed to maximize therapeutic benefits through the course of the disease. However, combination therapy raises complex questions and decisions for study sponsors, from preclinical research through clinical trial design to regulatory, statistical, and operational considerations. In January 2024, the Alzheimer's Drug Discovery Foundation convened an expert advisory board to discuss the key considerations in each of these areas.

Interdisciplinary, Computer-Guided Periodontal and Dental Management of a Novel Hypo- and Microdontia Case Restored With Ultrathin Veneers Fabricated via INKGLUE Technique.

Objectives: This report illustrates the digital interdisciplinary management of a case presenting with diastemata, a retained primary tooth, microdontia, and hypodontia. Esthetic crown lengthening and ultrathin veneers optimized the natural dentition and achieved a stable, minimally-invasive, and esthetically-pleasing outcome.

Clinical Considerations: Reduction guides were digitally-designed and 3D-printed for guided crown lengthening and dental veneer preparation.

Valentino's Syndrome in the Era of Advanced Imaging and Minimally Invasive Surgery.

Valentino's syndrome is a rare but potentially lethal differential diagnosis for acute appendicitis. We herein present the case of a 22-year-old male patient who presented to the emergency department with acute abdominal pain. Clinical suspicion of acute appendicitis was corroborated by analytical and imaging findings.

Influence of Opacifiers and Different Dentin Thicknesses on the Optical Properties of a Darkened Teeth with Limited Sound Tissue Reduction.

Objective: To evaluate color masking and relative translucency parameter (RTP) of increasing dentin thicknesses from different resin composites, with or without opacifiers, on a veneer dental preparation and resin disks.

Material And Methods: Artificial darkened lateral incisors with 1mm-thick veneers preparations were used to evaluate color masking of different resinous materials, with or without opacifiers: IPS Empress Direct (ED) with or without ED Opaque; and Essentia (ES) with or without ES Masking Liner. For the RTP test; disc-shaped specimens were performed and evaluated with a spectrophotometer (VITA Easyshade) against black and C4 backgrounds.