Publications by authors named "C B SACHETTI"
The COVID-19 pandemic generated a large volume of scientific productions with different quality levels. The speed with which knowledge was produced and shared worldwide imposed on health management the challenge of seeking ways to identify the best available evidence to support its decisions. In response to this challenge, the Department of Science and Technology of the Brazilian Ministry of Health started offering a service to produce and provide scientific knowledge addressing priority public health issues in the pandemic scenario.
View Article and Find Full Text PDFBackground Aims: The marketing authorization of Advanced Therapy Medicinal Products (ATMPs) in Brazil is recent. The features of these therapies impose specialized regulatory action and are consequently challenging for developers. The goal of this study was to identify the industry's experience in clinical development, marketing authorization and access to ATMPs through the Unified Health System (SUS, acronym in Portuguese), from a regulatory perspective.
View Article and Find Full Text PDFBackground Aims: Advanced therapy medicinal products (ATMPs) have reached the forefront of biotechnological innovation, partly due to public funders' efforts in the early stages of research and development (R&D). Data on investment in R&D of ATMPs are recognized as scarce, particularly in developing countries. Because of the numerous peculiarities of the Brazilian health system and the science and technology (S&T) system, the country is a good example for the evaluation of public investments in R&D of ATMPs.
View Article and Find Full Text PDFThis work aimed to evaluate the effects of drug therapies for coronavirus infections. Rapid systematic review with search in the MEDLINE, EMBASE, Cochrane, BVS, Global Index Medicus, Medrix, bioRxiv, Clinicaltrials.gov and International Clinical Trials Registry Platform databases.
View Article and Find Full Text PDFArticle Synopsis
- The Brazilian health system's advancement relies heavily on scientific and technological development, supported by the Ministry of Health through clinical research initiatives.
- A detailed analysis of the Ministry's research management database revealed that from 2002 to 2009, R$ 140 million was invested across various categories of clinical research, with a focus on basic biomedical research and clinical trials.
- Overall, these investments have fostered collaboration among researchers, health policies, and the healthcare industry, positioning Brazil competitively compared to other BRICS nations.